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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Methods and materials are well described in the publication.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 305 B (Bioaccumulation: Semi-static Fish Test)
- GLP compliance:
- no
- Specific details on test material used for the study:
- Anhydrous sodium perchlorate from EM Science, Gibbstown, NJ, USA. Concentration: 10 and 100 mg/L.
Publication also describes experiments with sodium arsenate. - Radiolabelling:
- no
- Details on sampling:
- - sampling times: d10, d30, d60 and d90 of study (during exposure phase)
- medium samples: twice a week when water is changed
- Water samples were stored at 4 °C prior to anlysis and analyzed within 2 weeks - Vehicle:
- no
- Details on preparation of test solutions, spiked fish food or sediment:
- 1/3 of each test solutions was twice a week.
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- Male zebrafish (Danio rerio) were used and supplied commercially by Ekkwill Waterlife Resources, Gibsonton, FL, USA. Fish were allowed to acclimate to laboratore conditions for two weeks before initiation of the experiment.
- Route of exposure:
- aqueous
- Test type:
- semi-static
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 90 d
- Total depuration duration:
- 5 d
- Test temperature:
- 23.4 +- 0.8 °C
- pH:
- 6.7 - 6.8
- Dissolved oxygen:
- 7.1 - 7.2 mg/L
- Salinity:
- 60.0. - 105.2 mg/L
- Conductivity:
- 122.3 - 218.3 mS/cm
- Reference substance (positive control):
- no
- Lipid content:
- 8.76 µg/kg bw d.w.
- Time point:
- other: day 10
- Lipid content:
- 8.73 µg/kg bw d.w.
- Time point:
- other: day 30
- Key result
- Conc. / dose:
- 10 mg/L
- Type:
- BCF
- Value:
- >= 0.12 - <= 0.14 dimensionless
- Key result
- Conc. / dose:
- 100 mg/L
- Type:
- BCF
- Value:
- >= 0.09 - <= 0.11 dimensionless
- Key result
- Elimination:
- yes
- Parameter:
- DT50
- Depuration time (DT):
- 25.7 h
- Key result
- Rate constant:
- other: uptake constant, 1/d
- Remarks:
- day 10
- Value:
- 0.018
- Key result
- Rate constant:
- other: uptake constant, 1/d
- Remarks:
- day 30
- Value:
- 0.018
- Key result
- Rate constant:
- other: uptake constant, 1/d
- Remarks:
- day 60
- Value:
- 0.023
- Key result
- Rate constant:
- other: uptake constant, 1/d
- Remarks:
- day 90
- Value:
- 0.025
- Key result
- Rate constant:
- overall depuration rate constant (d-1)
- Value:
- 0.64
- Details on results:
- Perchlorate concentrations were meausred on days 10, 30, 60 and 90 of the experiment. For the test solution with 10 mg/L of sodium perchlorate no results could be reported due to an accidental contamination of the fish samples by perchlorate. All values reported refer to a nominal concentration of 100 mg/L of sodium perchlorate.
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- The half-life time of perchlorate found in this study is 25.7 h after an exposure of 100 mg/L of sodium perchlorate.
The highest BCF was found to be 0.14.
Perchlorate can be considered as not bioaccumulative. - Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Methods and materials are well described in the publication.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Methods and materials are well described in the publication.
- GLP compliance:
- no
- Radiolabelling:
- no
- Vehicle:
- no
- Test organisms (species):
- Ictalurus punctatus
- Details on test organisms:
- The test animals were purchased from public hatcheries and acclimated to laboratory condition for at least 5 days. Dissolved oxygen, conductivity, temperature, pH, sallnity and un-ionized ammonia were measured.
- Route of exposure:
- aqueous
- Test type:
- semi-static
- Water / sediment media type:
- natural water: marine
- Total exposure / uptake duration:
- 5 d
- Total depuration duration:
- 20 d
- Test temperature:
- 17.5 - 20.9 °C
- pH:
- 6.8 - 7.3
- Dissolved oxygen:
- 55.8 - 93.1 %
- Salinity:
- 0.1 ppt
- Conductivity:
- 157.7 - 237.2 µS/cm
- Details on test conditions:
- This experiment was carried out with a static renewal design. One-third of the water in each tank was replaced every other day during the uptake and elimination phase. Water samples were taken from each aquarium for perchlorate analysis during the exposure period. Percent recovery and detection limits were determined from spiked perchlorate tissues (perchlorate solutions injected into fish prior to extraction) and adding known amounts of perchlorate to aqueous tissue extracts, respectively. A 10 g sample of the food used to feed the fish was also analyzed for perchlorate.
- Reference substance (positive control):
- no
- Key result
- Type:
- BCF
- Value:
- 0.21 dimensionless
- Basis:
- other: head
- Key result
- Type:
- BCF
- Value:
- 0.14 dimensionless
- Basis:
- other: skin
- Key result
- Type:
- BCF
- Value:
- 0.06 dimensionless
- Basis:
- other: filet
- Key result
- Type:
- BCF
- Value:
- 0.03 dimensionless
- Basis:
- other: muscle tissues
- Type:
- BCF
- Value:
- < 0.02 dimensionless
- Basis:
- other: kidney, liver, gill, gonad, gastrointestinal tract
- Key result
- Elimination:
- yes
- Parameter:
- DT50
- Remarks:
- half-life, head
- Depuration time (DT):
- 0.57 d
- Key result
- Elimination:
- yes
- Parameter:
- DT50
- Remarks:
- half-life, fillet
- Depuration time (DT):
- 0.41 d
- Key result
- Elimination:
- yes
- Parameter:
- DT50
- Remarks:
- half-life, liver
- Depuration time (DT):
- 0.88 d
- Key result
- Elimination:
- yes
- Parameter:
- DT50
- Remarks:
- half-life, gastrointestinal tract
- Depuration time (DT):
- 1.22 d
- Key result
- Elimination:
- yes
- Parameter:
- DT50
- Remarks:
- half-life, gills
- Depuration time (DT):
- 0.88 d
- Rate constant:
- other: uptake rate constant (1/d), head
- Value:
- 0.22
- Rate constant:
- other: uptake rate constant (1/d), fillet
- Value:
- 0.09
- Rate constant:
- other: uptake rate constant (1/d), liver
- Value:
- 0.013
- Rate constant:
- other: elimination rate constant (1/d), head
- Value:
- 1.22
- Rate constant:
- other: elimination rate constant (1/d), , fillet
- Value:
- 1.67
- Rate constant:
- other: elimination rate constant (1/d), liver
- Value:
- 0.79
- Rate constant:
- other: elimination rate constant (1/d), gastrointestinal tract
- Value:
- 1.22
- Rate constant:
- other: elimination rate constant (1/d), gills
- Value:
- 0.88
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The findings in this study suggest that perchlorate does not bioaccumulate, bioconcentrate, or hiomagnify in channel catfish as the BCF were 0.21 or lower.
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Methods and materials are well described in the publication.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Methods and materials are well described in the publication.
- GLP compliance:
- no
- Radiolabelling:
- no
- Vehicle:
- no
- Test organisms (species):
- other: Gambusie holbrooki
- Details on test organisms:
- Adult mosquitofish were purchased from a commercial hatchery (Ken's hatchery and Fish Farm, Alapaha, GA).
- Route of exposure:
- aqueous
- Test type:
- semi-static
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 30 d
- Total depuration duration:
- 20 d
- Hardness:
- 86.74 - 486.62 µS/cm
- Test temperature:
- 19.47 - 20.60 °C
- pH:
- 6.82 - 7.13
- Dissolved oxygen:
- 88.30 - 98.69%
- Details on test conditions:
- Fish were exposed to 0.1-1000 mg/l sodium perchlorate for 12 h, 1, 2, S, 10, and 30 days, and perchlorate was determined in whole body extracts.
- Nominal and measured concentrations:
- concentrations of potassium perchlorate (mg/L): 0.0; 0.1; 1.0; 10; 100; 1000
- Reference substance (positive control):
- no
- Conc. / dose:
- 1 mg/L
- Type:
- BCF
- Basis:
- whole body w.w.
- Time of plateau:
- 2 d
- Remarks on result:
- not determinable
- Remarks:
- no perchlorate detected
- Key result
- Conc. / dose:
- 1 mg/L
- Type:
- BCF
- Value:
- 0.27 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 10 d
- Key result
- Conc. / dose:
- 1 mg/L
- Type:
- BCF
- Value:
- 0.06 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 30 d
- Key result
- Conc. / dose:
- 10 mg/L
- Type:
- BCF
- Value:
- 0.35 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 2 d
- Key result
- Conc. / dose:
- 10 mg/L
- Type:
- BCF
- Value:
- 0.11 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 10 d
- Key result
- Conc. / dose:
- 10 mg/L
- Type:
- BCF
- Value:
- 0.18 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 30 d
- Key result
- Conc. / dose:
- 100 mg/L
- Type:
- BCF
- Value:
- 0.17 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 2 d
- Key result
- Conc. / dose:
- 100 mg/L
- Type:
- BCF
- Value:
- 0.12 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 10 d
- Key result
- Conc. / dose:
- 100 mg/L
- Type:
- BCF
- Value:
- 0.14 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 30 d
- Key result
- Conc. / dose:
- 1 000 mg/L
- Type:
- BCF
- Value:
- 0.09 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 2 d
- Key result
- Conc. / dose:
- 1 000 mg/L
- Type:
- BCF
- Value:
- 0.06 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 10 d
- Key result
- Conc. / dose:
- 1 000 mg/L
- Type:
- BCF
- Value:
- 0.13 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 30 d
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The highest BCF found for eastern mosquitofish (Gambusie holbrooki) was 0.35. The results suggest that perchlorate is not bioaccumulative.
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
- BCF (aquatic species):
- 0.35 dimensionless
Additional information
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