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Diss Factsheets
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EC number: 231-912-9 | CAS number: 7778-74-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Justification for type of information:
- The studies were perfomred according to OECD guidelines without being conducted under GLP conditions. No detailed information on raw data are provided.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 207 (Earthworm, Acute Toxicity Tests)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 222 (Earthworm Reproduction Test (Eisenia fetida/Eisenia andrei))
- Deviations:
- not specified
- GLP compliance:
- no
- Specific details on test material used for the study:
- A 100 µg/mL certified perchlorate standard, granular sodium perchlorate and ammonium perchlorate were used to prepare the perchlorate solutions. All solutions were prepared in Milli-Q reverse osmosis water.
- Test organisms (species):
- Eisenia fetida
- Animal group:
- annelids
- Study type:
- laboratory study
- Remarks:
- acute and long-term tests
- Substrate type:
- other: the test were conducted on filter, on sand or in artificial soil
- Limit test:
- no
- Test temperature:
- 22 °C
- Details on test conditions:
- Mortality was the clinical endpoint examined in the 14-day acute toxicily tests. Mortality was recorded daily during each study. Earthwonns were classified as dead when they did not respond to a gentle mechanical stimulus at the anterior end.
- Nominal and measured concentrations:
- acute toxicity test, filter paper:
Nominal concentrations: 0, 0.1, 1, 700, 7000, 35000, 70000 µg/mL based on perchlorate anion
acute toxicity test, sand:
Nominal concentrations in sand: 0, 0.1, 1, 1000, 2000, 5000, 10000 µg/g based on perchlorate anion
reproductive toxicity test, artificial soil:
Nominal concentrations in soil: 0, 0.1, 10, 100, 1000 µg/g based on perchlorate anion
reproductive toxicity test, sand:
Nominal concentrations in sand: 0, 0.1, 1, 1000, 2000, 5000, 10000 µg/g based on perchlorate anion - Reference substance (positive control):
- no
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 4 150 other: µg/mL
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- based on perchlorate anion
- Basis for effect:
- mortality
- Remarks on result:
- other: on filter paper
- Key result
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 2 550 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- based on perchlorate anion
- Basis for effect:
- mortality
- Remarks on result:
- other: in sand
- Key result
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 350 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- based on perchlorate anion
- Basis for effect:
- reproduction
- Remarks:
- cocoon production
- Remarks on result:
- other: in sand
- Key result
- Duration:
- 28 d
- Dose descriptor:
- EC50
- Effect conc.:
- 1.3 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- based on perchlorate anion
- Basis for effect:
- reproduction
- Remarks:
- cocoon production
- Remarks on result:
- other:
- Remarks:
- in artificial soil
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The LC50 value for Eisenia fetida according to this study can be stated to be 2550 mg/kg dw for an exposure time of 14 days in sand.
The EC50 value for Eisenia fetida according to this study can be stated to be 350 mg/kg dw for an exposure time of 28 days in sand and 1.3 mg/kg dw in artificail soil, respectively.
Reference
14 -day filter contact test with sodium perchlorate
perchlorate concentration (µg/mL) | number of earthworms survived/total number |
0 | 5/5 |
0.1 | 3/5 |
1 | 2/5 |
700 | 4/5 |
7000 | 1/5 |
35,000 | 0/5 |
70,000 | 0/5 |
14 -day filter contact test with ammonium perchlorate
perchlorate concentration (µg/mL) | number of earthworms survived/total number |
0 | 5/5 |
0.1 | 4/5 |
1 | 4/5 |
1000 | 5/5 |
10,000 | 0/5 |
50,000 | 0/5 |
100,000 | 0/5 |
14 -day test in sand with sodium perchlorate
perchlorate concentration (µg/mL) | number of earthworms survived/total number |
0 | 10/10 |
0.1 | 10/10 |
1 | 10/10 |
1000 | 9/10 |
2000 | 7/10 |
5000 | 0/10 |
10,000 | 0/10 |
4 -week cocoon production test in artificial soil with sodium perchlorate
perchlorate concentration (µg/mL) | average cocooosn produced |
0 | 2.0 |
0.1 | 1.25 |
10 | 2.0 |
100 | 0.75 |
1000 | 0 |
Description of key information
The LC50 value for Eisenia fetida according to this study can be stated to be 2550 mg/kg dw for an exposure time of 14 days in sand.
Key value for chemical safety assessment
- Short-term EC50 or LC50 for soil macroorganisms:
- 2 550 mg/kg soil dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.