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EC number: 203-783-9 | CAS number: 110-61-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study performed before test guidelines and GLP principles were in place. No details given on the test animals used; Analytical data of substance concentration not included; no cage side observations/ body weight recordings after exposure; no necropsy on dead animals; no details on housing after exposure. No details on test substance (Lot/Batch number; purity). Due to the physical properties of the substance it is not possible Because of the characteristics of the material, it is difficult to generating aerosol.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Analytical data of substance concentration not included; no cage side observations/ body weight recordings after exposure; no necropsy performed.
- GLP compliance:
- no
- Remarks:
- Study was conducted before GLP principles were in force.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Succinonitrile
- EC Number:
- 203-783-9
- EC Name:
- Succinonitrile
- Cas Number:
- 110-61-2
- Molecular formula:
- C4H4N2
- IUPAC Name:
- butanedinitrile
- Details on test material:
- - Substance type: colourless solid
- Analytical purity: Not described
- Purity test date: Not described
- Lot/batch No.: Not described
- Melting temperature: 57°C
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not described
- Age at study initiation: not described
- Weight at study initiation: not described
- Fasting period before study: not described
- Housing: not described
- Diet: stock diet ad libitum
- Water: tap water ad libitum
- Acclimation period: not described
ENVIRONMENTAL CONDITIONS
No details given
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: stainless steel /glass exposure chamber
- Exposure chamber volume: 1.5m3
- Method of holding animals in test chamber: individually kept in wire screen cages
- Airflow: 2.16 m3/h
- Method of conditioning air: not described
- System of generating aerosols: substance was dispersed at 90°C by stainless steel/ glass aerodynamic nozzle nebulizer to fine mist
- Method of particle size determination: by Cascade Impactor
- Treatment of exhaust air: not described
- Temperature, humidity, pressure in air chamber: not described
TEST ATMOSPHERE
- Brief description of analytical method used: Twenty-five liter samples of the atmosphere was drawn through a Cambridge glassfiber filter. Filter was weighed before an dafter the sampling to determine concentration
- Samples taken from breathing zone: yes
- Particle size distribution: 1.5 - 8.3 µm (3-5.9 µm (95%)) - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetrically
- Duration of exposure:
- 4 h
- Concentrations:
- 2.67 mg/l air
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: daily, no weighing
- Necropsy of survivors performed: no
- No other examinations performed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 2.67 mg/L air
- Based on:
- test mat.
- Remarks on result:
- other: maximum attainable concentration
- Mortality:
- None of the animals died during the exposure period, but three males died within 48 hours after termination of the exposure.
- Clinical signs:
- other: The rats could not be observed during exposure due to invisibility caused by the dense mist. No observations after exposure described.
Applicant's summary and conclusion
- Interpretation of results:
- sligthly toxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an inhalation toxicity study with rats in accordance with the current OECD guideline, the 4-hour LC50 was found to be higher than 2.67 mg/l of air. At the highest attainable concentration, only three out of ten animals died and thus the substance does not have to be classified for inhalation toxicity according to CLP Regulation (EC) 1272/2008.
- Executive summary:
An inhalation toxicity study was performed with 5 male and 5 female rats in accordance with the current OECD guideline. The rats were exposed whole body to the substance by aerosols at the maximal attainable concentration. None of the animals died during the exposure period, but three males died within 48 hours after termination of the exposure. It was concluded that the 4-hour LC50 was higher than 2.67 mg/l of air. Since the LC50 was found to be higher than the highest attainable concentration, the substance does not have to be classified for inhalation toxicity according to CLP Regulation (EC) 1272/2008.
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