Registration Dossier
Registration Dossier
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EC number: 601-017-1 | CAS number: 110964-79-9
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study performed according to current OECD-Guideline and GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-methanesulfonyl-2-nitrobenzoic acid
- EC Number:
- 601-017-1
- Cas Number:
- 110964-79-9
- Molecular formula:
- C8 H7 N1 O6 S1
- IUPAC Name:
- 4-methanesulfonyl-2-nitrobenzoic acid
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
Results and discussion
% Degradation
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 3
- Sampling time:
- 28 d
- Details on results:
- Cumulative C02 production in the controls (47.3 and 45.7 mg CO2) was within the acceptable range for this assay system. The degradation of sodium benzoate was rapid and achieved 64% of its TCO2 after 6 days and 82% after 29 days.
The degradation of sodium benzoate was also rapid in the presence of NMSBA and achieved 64% of itsTCO2 after 6 days.
Mean cumulative CO2 production by mixtures containing NMSBA was negligible and was equivalent, at most, to 3% of the theoretical value.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- Cumulative C02 production in the controls (47.3 and 45.7 mg CO2) was within the acceptable range for this assay system. The degradation of sodium benzoate was rapid and achieved 64% of its TCO2 after 6 days and 82% after 29 days.
The degradation of sodium benzoate was also rapid in the presence of NMSBA and achieved 64% of itsTCO2 after 6 days.
Mean cumulative CO2 production by mixtures containing NMSBA was negligible and was equivalent, at most, to 3% of the theoretical value.
NMSBA cannot, therefore, be considered as readily biodegradable
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