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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Relevant methodological deficiencies

Data source

Reference
Reference Type:
publication
Title:
The bone marrow clastogenicity of eight halogenated benzenes in male NMRI mice
Author:
Mohtashamipur E, Triebel R, Straeter H, Norpoth K
Year:
1987
Bibliographic source:
Mutagenesis 2, 111-113 (1987)

Materials and methods

Principles of method if other than guideline:
m-dichlorobenzene was tested for acute toxicity (LD50) by intraperitoneal administration
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
other: liquid
Details on test material:
purity: 99.0%

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
not specified
Doses:
no data
No. of animals per sex per dose:
no data
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
1 061 mg/kg bw
Based on:
test mat.
Dose descriptor:
other:
Remarks:
Study is not reliable (reliability 3) and therefore not relevant for assessment.

Any other information on results incl. tables

no data

Applicant's summary and conclusion

Executive summary:

m-dichlorobenzene was tested for acute toxicity (LD50) by intraperitoneal administration to NMRI mice. The LD50 was 1061 mg/kg bw.