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Physical & Chemical properties

Vapour pressure

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Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2016
Report Date:
2016

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Qualifier:
according to
Guideline:
EPA OPPTS 830.7950 (Vapor Pressure)
GLP compliance:
yes
Type of method:
effusion method: by loss of weight or by trapping vaporisate

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Name of test material (as cited in study report): Ethyl Ascorbic acid
Physical state: White to very pale yellow crystalline powder
Test item storage: In freezer (≤ -15°C) desiccated
Stability: Stable under storage conditions until 21 April 2018 (retest date)

Results and discussion

Vapour pressureopen allclose all
Temp.:
20 °C
Vapour pressure:
<= 0 Pa
Temp.:
25 °C
Vapour pressure:
<= 0 Pa

Any other information on results incl. tables

Results

The results of the isothermal TGA analysis for the test item and the vapour pressure at 20 °C and 25 °C are given in Tables 1 and 2.

Table 1: Results of the isothermal TGA analysis

Temperature

[°C]

Weight loss

[μg/min]

VT

[g/cm2/h]

log VT

log PT

PT

[Pa]

140

3.065

3.66E-04

-3.44

0.63

4.3

 

4.169

4.98E-04

-3.30

0.73

6.1

150

7.997

9.55E-04

-3.02

1.11

13

 

8.769

1.05E-03

-2.98

1.15

14

160

17.44

2.08E-03

-2.68

1.49

31

 

18.34

2.19E-03

-2.66

1.52

33

170

34.93

4.17E-03

-2.38

1.84

69

 

35.69

4.26E-03

-2.37

1.85

70

 

Table 2: Vapour pressure of the test item

Temperature [°C]

log PT

PT[Pa]

PT[mmHg]

20

-6.15

7.1E-07

5.3E-09

25

-5.75

1.8E-06

1.3E-08

 

Conclusion

The isothermal TGA effusion method was applied for the determination of the vapour pressure of Ethyl Ascorbic acid. The weight losses of the test item were obtained at temperatures above the melting temperature of the test item because no significant weight loss of the test item was observed below the melting temperature. According to this, the vapour pressure at 20°C and 25°C might be overestimated.

The vapour pressure of the test item at 20 °C (293K) and 25 °C (298K) was therefore reported as equal or less than values.

 

 

20 °C

25 °C

[Pa]

[mmHg]

[Pa]

[mmHg]

Test item

<7.1-07

<5.3E-09

<1.8E-06

<1.3E-08

Applicant's summary and conclusion