L-Ascorbic acid, 3-O-ethyl-

Explosiveness

Administrative data

Endpoint:

explosiveness

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2013

Report date:

2013

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.14 (Explosive properties)

Deviations:

yes

Remarks:

The thermal stability was determined by differential thermal analysis DSC (Differential Scanning Calorimetry).

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one

EC Number:

617-849-3

Cas Number:

86404-04-8

Molecular formula:

C8H12O6

IUPAC Name:

(5R)-5-[(1S)-1,2-dihydroxyethyl]-4-ethoxy-3-hydroxy-2,5-dihydrofuran-2-one

Test material form:

solid: particulate/powder

Results and discussion

Small-scale preliminary tests

Small-scale preliminary tests 1

Parameter:

other: More sensitive to shock than m-dinitrobenzene

Remarks:

migrated information

Remarks on result:

not measured/tested

Small-scale preliminary tests 2

Parameter:

other: More sensitive to friction than m-dinitrobenzene

Remarks:

migrated information

Remarks on result:

not measured/tested

Small-scale preliminary tests 3

Parameter:

other: Explosive under influence of flame

Remarks:

migrated information

Remarks on result:

not measured/tested

Small-scale preliminary tests 4

Parameter:

other: Explosive (not specified)

Remarks:

migrated information

Remarks on result:

negative (not further specified)

Any other information on results incl. tables

The thermal stability was determined by differential thermal analysis DSC (Differential Scanning Calorimetry). Samples of the test item and of a reference material (empty crucible) are subjected to the same controlled temperature programme. When the test substance undergoes a phase transition or decomposition the corresponding change of enthalpy gives an endothermic (melting) or exothermic (caused by freezing or decomposition) departure from the base line of the temperature record.

Results (scan with 4°C/min)

Sample	Description	Fig.	Thermal signal Range [°C]Peak-temperature [°C]	Energy [kJ/kg]
917181.13.0544.01LIMS Nr. 21364	lot: LT005923	1a	Endo: 106 -121,112Exo: 239 -318,289	-128520
ídem	idem	1b	Endo: 106 - 123, 113Exo: 236 - 323, 289	-126516

Applicant's summary and conclusion

Interpretation of results:

non explosive

Remarks:

Migrated information

Conclusions:

As stated in the reference (Commission Regulation (EC) No 440/2008, Annex A.14, § 1.1) “the tests need not to be performed when available thermodynamic information (e.g. heat of formation, heat of decomposition) and/or absence of certain reactive groups in the structural formula establishes beyond reasonable doubt that the substance is incapable of rapid decomposition with evolution of gases or release of heat (i.e. the material does not present any risk of explosion).”
1. The determination of the thermal stability of the test substance by DSC (Differential Scanning Calorimetry) - Figures 1 a/b show that between 30°C and 400°C the exothermal decomposition energy is about 518 kJ/kg and therefore slightly above the limit of 500 kJ/kg for exclusion given in the Regulation (EC) No 1272/2008 (CLP) of the European Parliament and of the Council of 16 December 2008 on classification, labelling and packaging of substances and mixtures, Chapter 2.1.4.3. (c).
2. According to the chemical structure and the list of reactive groups that could have explosive properties in Bretherick’s Handbook of Reactive Chemical Hazards, Butterworths, 4th edition, it can be excluded that the tested substance has explosive properties.