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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
genetic toxicity in vitro
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Test item: estradiol-methyl-ether-acetateCAS No.: 5976-55-6Physical state: white crystalline powderStorage:15-30 °C, protected from light and wet

Results and discussion

Test results
Remarks on result:
no mutagenic potential (based on QSAR/QSPR prediction)

Any other information on results incl. tables

Software Database / Method Species Predicted value
VegaNIC Benigni-Bossa Mutagenicity (TOXTREE) S.typhimurium (alerts) NON-mutagen
VegaNIC Mutagenicity model (CAESAR)  S.typhimurium (alerts) NON-mutagen
VegaNIC Mutagenicity SarPy model  S.typhimurium (alerts) NON-mutagen
ChemProp Mutagenicity by Kazius et al.  S.typhimurium (alerts) Not active mutagen

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: VegaNIC, ChemProp, the predicted values indicated that estradiol-methyl-ether-acetate is not mutagen.