Registration Dossier

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Test item: estradiol-methyl-ether-acetateCAS No.: 5976-55-6Physical state: white crystalline powderStorage:15-30 °C, protected from light and wet

Results and discussion

Effect concentrationsopen allclose all
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.206 mg/L
Nominal / measured:
estimated
Remarks on result:
other: Toolbox Database: Aquatic OASIS
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.34 mg/L
Nominal / measured:
estimated
Remarks on result:
other: VegaNIC (EPA)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
0.28 mg/L
Nominal / measured:
estimated
Remarks on result:
other: T.E.S.T. (CM)
Details on results:
Pimephales promelas (Fathead minnow)

Applicant's summary and conclusion

Conclusions:
According to (Q)SAR modells: QSAR Toolbox, VegaNIC, T.E.S.T., the predicted values indicated that estradiol-methyl-ether-acetate is hazardous to the fish. The result meets the requirement of Aquatic Acute Category 1.