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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation
Remarks:
other: Structural alerts
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
results derived from a (Q)SAR model, with limited documentation / justification
Justification for type of information:
QSAR prediction

Data source

Reference
Reference Type:
other: Predicted data
Title:
Unnamed
Year:
2015

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs R.6, May/July2008
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: crystalline
Details on test material:
Test item: estradiol-methyl-ether-acetateCAS No.: 5976-55-6Physical state: white crystalline powderStorage:15-30 °C, protected from light and wet

Results and discussion

In vivo (non-LLNA)

Results
Remarks on result:
no indication of skin sensitisation
Remarks:
QSAR prediction

Any other information on results incl. tables

Software Method Endpoint Alert Predicted value
ChemProp Enoch et al Skin Sensitisation No Structural Alerts were found. Not active sensitiser
Toxtree Skin sensitisation reactivity domains Skin Sensitisation No Structural Alerts were found. No alerts

Applicant's summary and conclusion

Interpretation of results:
not sensitising
Conclusions:
According to (Q)SAR modells: Toxtree, ChemProp, the predicted values indicated that Estradiol-methyl-ether-acetate is not sensitiser.