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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is form peer- reviewed journal

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology,1973
Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
Chemidplus Database,U.S. National Library of Medicine,2018
Reference Type:
publication
Title:
Acute oral toxicity of test chemical in rats
Author:
Richard J. Lewis
Year:
2012
Bibliographic source:
Sax's Dangerous Properties of Industrial Materials, 12th Edition, 5 Volume Set,2012
Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
Jay A. Brown
Year:
2018
Bibliographic source:
Haz-Map®: Information on Hazardous Chemicals and Occupational Diseases, U.S. National Library of Medicine, October 2018.
Reference Type:
other: authoritative database
Title:
Acute oral toxicity study of test chemical in Rat
Author:
U.S. National Library of Medicine
Year:
2018
Bibliographic source:
HSDB (Hazardous Substances Data Bank); US national Library of Medicine,2018
Reference Type:
other: Secondary source
Title:
Acute oral toxicity of test chemical in rats
Author:
RTECS
Year:
2018
Bibliographic source:
RTECS (registry of toxic effect of chemical substance database), 2018
Reference Type:
other: authoritative database
Title:
Acute oral toxicity of test chemical in rats
Author:
National Center for Biotechnology Information
Year:
2018
Bibliographic source:
PubChem open chemistry database,2018

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Acute Oral toxicity test was carried out to study the effects of test chemical on rats.
GLP compliance:
not specified
Test type:
other: no data
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report):β -Bromostyrene ((2-bromovinyl)benzene)
- Molecular formula :C8H7Br
- Molecular weight :183.0473 g/mole
- Substance type:Organic
- Physical state:Liquid
- Impurities (identity and concentrations):0.4%

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
1250 mg/kg bw
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 250 mg/kg bw
Based on:
test mat.
95% CL:
>= 8 200 - <= 189 000
Remarks on result:
other: 50 % mortality observed
Mortality:
50% mortality was observed in treated rat at dose 1250 mg/kg bw.
Clinical signs:
not specified
Body weight:
not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Conclusions:
The lethal concentration (LD50) value for acute oral toxicity test was considered to be 1250 mg/kg bw (95% CI: 8200-189000),when rats were treated with test chemical orally.
Executive summary:

Acute oral toxicity study was performed in rats using test chemical.50% mortality was observed at dose 1250 mg/kg bw. Hence,LD50 value was considered to be 1250 mg/kg bw(95% CI: 8200-189000),when rats were treated with test chemical orally.