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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from peer reviewd journals

Data source

Reference
Reference Type:
review article or handbook
Title:
Fragrance raw material monograph: Bromostyrol
Author:
D. L. J. Opdyke
Year:
1973
Bibliographic source:
Food and Cosmetics Toxicology. Vol. 11, Pg. 1043, 1973

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
To assess the dermal irritation potential of test chemical in humans
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): (2-bromovinyl)benzene
- Molecular formula: C8H7Br
- Molecular weight: 183.0473 g/mol
- Smiles notation: c1(ccccc1)/C=C/Br
- InChl : 1S/C8H7Br/c9-7-6-8-4-2-1-3-5-8/h1-7H/b7-6+
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
other: humans
Strain:
other: not applicable
Details on test animals and environmental conditions:
No data

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
other: Petrolatum
Controls:
not specified
Amount / concentration applied:
4% in petrolatum
Duration of treatment / exposure:
48 hr
Observation period:
48 hr
Number of animals:
25 subjects
Details on study design:
no data available

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
48 h
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
The test chemical was not irritating to human skin after 48 hours exposure.
Executive summary:

A skin irritation study was performed on humans to assess the irritation potential of test chemical.

The test chemical was tested 4% in petrolatum in 25 human volunteers in 48 hours closed patch test.

No signs of irritation were observed after 48 hours of exposure.

Hence, the test material was considered not irritating to human skin.