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EC number: 246-896-9 | CAS number: 25360-10-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2012-02-10 to 2012-02-20
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study is classified reliable without restriction. The study followed GLP and adhered to OECD Guideline 405 recommendations.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 1,1-dimethylheptanethiol
- EC Number:
- 246-896-9
- EC Name:
- 1,1-dimethylheptanethiol
- Cas Number:
- 25360-10-5
- Molecular formula:
- C9H20S
- IUPAC Name:
- 3,5-dimethylheptane-3-thiol
- Test material form:
- other: Clear liquid
- Details on test material:
- - Name of test material (as cited in study report): Tert-Nonanethiol
- Substance type: Aliphatic Thiol
- Physical state: Liquid
- Analytical purity: 97.58%
- Lot/batch No.: 2011-11-1629
- Stability under test conditions: Stable
- Storage condition of test material: Room temperature and in the dark
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Commercial Breeder (name not reported)
- Age at study initiation: 19 to 20 weeks of age
- Weight at study initiation: 3.40 to 3.53 Kg
- Housing: individually in a plastic cage with perforated floors
- Diet (e.g. ad libitum): 125 g of a standard laboratory rabbit diet per day
- Water (e.g. ad libitum): ad libitum
- Acclimation period: Five weeks
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 16 to 20°C
- Humidity (%): 40 to 70%
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light): 12 hrs dark/12 hrs light
IN-LIFE DATES: Not reported
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL undiluted - Duration of treatment / exposure:
- Single exposure followed by 72 hours observation period
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 3
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
SCORING SYSTEM: See 'Any other information on materials and methods' section below
TOOL USED TO ASSESS SCORE: ophthalmoscope or pencil beam torch
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hour
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hour
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hour
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24, 48, and 72 hour
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- Slight discharge was apparent in the treated eye of each animal one hour after instillation and the animals were overtly normal from 24 hours after instillation. Instillation of the test material gave rise to no or practically no initial pain response.
- Other effects:
- There was no sign of toxicity or ill health in any rabbit during the observation period.
Any other information on results incl. tables
Table 1. means 24, 48, and 72 hour scores for the ocular reactions
24-, 48-, and 72 hour scores |
Corneal Opacity |
Iridial Lesions |
Conjunctiva |
|
Redness |
Chemosis |
|||
Mean for 3 animals |
0 |
0 |
0 |
0 |
EC Category 1 trigger values* |
≥3 |
>1.5 |
|
|
EC Category 2 trigger values* |
≥1 |
≥1 |
≥2 |
≥2 |
* Classification triggered if any value is attained by two or more animals.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Tert-nonanethiol is not considered to be an ocular irritant based on the results obtained in this study in the rabbit.
- Executive summary:
In an ocular irritation study, three New Zealand White rabbits were administered a single ocular dose (0.1 mL) of tert-nonanethiol and observed for 72 hours after instillation. The test material was instilled into the right eye by pulling the lower eyelid away from the eye ball to form a cup into which the test substance was dropped. The eyelids were then gently held together for one second before releasing; the left eye remained untreated. The treated eyes were not irrigated or rinsed after instillation.
There was no sign of toxicity or ill health in any rabbit during the observation period. Slight discharge was apparent in the treated eye of each animal one hour after instillation and the animals were overtly normal from 24 hours after instillation. Instillation of the test material gave rise to no or practically no initial pain response.
Tert-nonanethiol did not produce any ocular irritation in this study.
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