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Diss Factsheets
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EC number: 800-777-3 | CAS number: 1351378-24-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 - 30 May 2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 012
- Report date:
- 2012
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- GROUPE INTERMINISTERIEL DES PRODUITS CHIMIQUES
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- dioxomolybdenum; oxonickel; trioxotungsten
- EC Number:
- 800-777-3
- Cas Number:
- 1351378-24-9
- Molecular formula:
- (Ni)z(Mo)x(W)yO(13 – 20)x
- IUPAC Name:
- dioxomolybdenum; oxonickel; trioxotungsten
- Test material form:
- other: grains
- Details on test material:
- - Name of test material (as cited in study report): 2-Butenedioic acid (2Z)-, reaction products with ammonium di-µ3-hydroxyhexacosa-µ-oxododecaoxododecatungstate(6-) (6:1), ammonium octa-µ-oxodi-µ3-oxo-µ4-oxododecaoxoheptamolybdate(6-) (6:1), nickel(2+) nitrate (1:2) and nickel(2+) sulfate (1:1)
- Physical state: green grains
- Analytical purity: > 99%
- Lot/batch No.: 19266-184-1
- Expiration date of the lot/batch: May 2018
- Storage condition of test material: at room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage JANVIER, Le Genest St Isle, France
- Age at study initiation: 8 - 9 weeks
- Weight at study initiation: 183 - 231 g
- Fasting period before study: animals were fasted one day prior to substance administration until 4 hrs after substance administration (diet only).
- Housing: 3 animals per cage in solid-bottomed clear polycarbonate cages with stainless steel mesh lids
- Diet: M20 (pelleted), Specific Diet Services, ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 - 25
- Humidity (%): 30 - 70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 / 12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- olive oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle:
2000 mg/kg bw: 200 mg/mL
300 mg/kg bw: 30 mg/mL
- Amount of vehicle (if gavage): 10 mL/kg bw
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg bw - Doses:
- 300 and 2000 mg/kg bw
- No. of animals per sex per dose:
- 3 (controls), 12 (test substance group; 3 animals per step in a two-step testing procedure with 2 concentrations)
- Control animals:
- other: 3 animals received 10 mL/kg bw olive oil via gavage in a current control study performed from 14 Feb - 28 Feb 2012
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: animals were observed 0.5, 1, 3 and 4 h after substance administration and daily thereafter and individual body weights were determined periodically on day 0 (prior to substance administration), 2, 7 and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, other: macroscopical examination of oesophagus, stomach, duodenum, jejunum, ileon, caecum, colon, rectum, spleen, liver, thymus, trachea, lungs, heart, kidneys, urinary bladder, ovaries, uterus, adrenals and pancreas
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: LD50 cut-off according to OECD 423
- Mortality:
- 2000 mg/kg bw: In the first step, 2/3 animals died (2 or 4 days after substance application); in the second step, 3/3 rats died (Day 2, 3 and 4)
300 mg/kg bw: No mortality was observed during the study period.
For details, please refer to Table 1 under "Any other information on results". - Clinical signs:
- other: 2000 mg/kg bw: Mortalities were preceded by a decrease in muscle tone and piloerection in 2/5 and 5/5 rats, respectively. The surviving high-dose animal showed piloerection after dosing. 300 mg/kg bw: Decreased spontaneous activity and piloerection was o
- Gross pathology:
- 2000 mg/kg bw: Non-surviving animals: Rigor mortis was noted before necropsy in 5/5 animals. Marked lysis preventing macroscopical examinations was observed in 3/5 animals. Examination of the other animals revealed thinning of the forestomach in 1/5 animals with red coloration, black coloration of the forestomach, black coloration of the corpus (1/5) and thinning of the corpus (2/5).
Surviving animals: The surviving high-dose animal revealed a thickening of the forestomach.
300 mg/kg bw: Macroscopical examinations revealed no substance-related findings.
Any other information on results incl. tables
Table 1. Mortality and clinical signs after test substance administration.
Dose |
Toxicological results* |
Duration of clinical signs |
Time of death |
Mortality (%) |
Females |
||||
300 |
3/2/6 |
0.5 – 3 h |
--- |
0 |
2000 |
5/6/6 |
0.5 h - Day 3 |
Day 2, |
83% |
LD50 cut off = 1000 mg/kg bw |
* first number = number of dead animals
second number = number of animals with clinical signs
third number = number of animals used
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- CLP: Acute Oral 4, H302
DSD: Xn, R22
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