Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Long-term toxicity testing of 1,2-dichloropropane to daphnid (Daphnia magna) and mysid (Mysidopsis bahia) was conducted under GLP and in general occordance with standard test methods.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 8.3 mg/L
Marine water invertebrates
Marine water invertebrates
- Effect concentration:
- 4.09 mg/L
Additional information
The long-term 21-day exposure of the freshwater invertebrate (Daphnia magna) to 1,2 -dichloroproane by Dow (1988) was selected as the key study for long-term toxicity to freshwater invertevbrates since it was conducted under flow-through conditions with measured confirmation of dose, in general accordance to standard test methods, and under GLP. The 21-day NOEL was 8.3 mg/l, the LOEL was 15.8 mg/L and the maximum acceptable toxicant concentration (MATC) was 11.4 mg/L. All statistical analyses were performed using reproduction data (the most sensitive biological parameter measured).
The long-term 28 -day exposure of the marine invertebrate (mysidopsis bahia) to 1,2 -dichloropropane by Dow (1989) was selected as the key study for long-term toxicity to marine water invertebrates, since it was conducted under flow-through conditions with measured confirmation of doses, in general accordance with standard test methods, and under GLP. No concentration-mortality response relationship and no statistical effect on survival of parental mysids, no apparent effect on time to first brood released, and no significant differences in the growth parameters between the controls and 1,2 -dichloropropene exposed mysids was observed in the study; therefore, a LOEC was not established due to lack of any significant effects on parental mysid survival, growth or reproduction. The NOEC was 4.09 mg/L and the MATC (Maximum Acceptable Toxicant Concentration) was > 4.09 mg/L, the highest 1,2-dichloropropane concentration tested.
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