Registration Dossier
Registration Dossier
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EC number: 232-260-8 | CAS number: 7803-51-2
Carcinogenicity
Administrative data
Description of key information
The study was performed on rats during 104 weeks. NOAEC (carcinogenicity) > 3 ppm (4.26 mg/m3).
No treatment-related changes suggestive of a toxic or carcinogenic effect were observed.
Key value for chemical safety assessment
Carcinogenicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 4.26 mg/m³
Justification for classification or non-classification
Phosphine is listed on Annex VI to Regulation (EC) No 1272/2008 includes lists of harmonised classification and labelling. No change is proposed for these effects.
Additional information
In a chronic toxicity and carcinogenicity study of phosphine (Newton et al., 1999), 60 male and female F344 rats per group were exposed via whole-body inhalation to 0.3, 1 or 3 ppm phosphine. No histomorphologic alterations attributable to phosphine exposure were seen. In conclusion, under the conditions of this study, there were no treatment-related changes suggestive of a toxic or carcinogenic effect seen in rats.
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