Registration Dossier
Registration Dossier
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EC number: 232-260-8 | CAS number: 7803-51-2
Neurotoxicity
Administrative data
Description of key information
Schaefer (1998) observed no phosphine-related clinical and neuropathologic changes in subchronic and acute studies.
Key value for chemical safety assessment
Effect on neurotoxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 4.23 mg/m³
Additional information
Schaefer (1998) observed no neurotoxic effect on rat during a subchronic study and a phosphine-related decrease in horizontal activity, vertical activity, total distance and stereotype in a acute study with 21 ; 28 and 40 ppm. These effects was observed on day 1 but not 7 and 14 days later. In conclusion, no phosphine-related clinical and neuropathologic changes were found in subchronic and acute studies.
Justification for classification or non-classification
Phosphine is listed on Annex VI to Regulation (EC) No 1272/2008 includes lists of harmonised classification and labelling. No change is proposed for these effects.
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