Brief Profile

The Brief Profile summarizes the non-confidential data on substances as it is held in the databases of the European Chemicals Agency (ECHA), including data provided by third parties. The Brief Profile is automatically generated; note that it does not currently distinguish between harmonised classification and minimum classification; information requirements under different legislative frameworks may therefore not be fully up to date or complete. For accuracy reasons, substance manufacturers and imports have the responsibility to consult official sources, e.g. the electronic edition of the Official Journal of the European Union.
This Brief Profile is covered by the ECHA Legal Notice.

Substance Description

Substance identity

EC / List no.:
216-823-5
CAS no.:
1675-54-3
Index number:
Molecular formula:
C21H24O4
SMILES:
CC(C)(C1=CC=C(OCC2CO2)C=C1)C1=CC=C(OCC2CO2)C=C1
InChI:
InChI=1/C21H24O4/c1-21(2,15-3-7-17(8-4-15)22-11-19-13-24-19)16-5-9-18(10-6-16)23-12-20-14-25-20/h3-10,19-20H,11-14H2,1-2H3
Type of substance:
Multi constituent substance
Origin:
Organic
Registered compositions:
2
Of which contain:
7 impurities relevant for classification
0 additives relevant for classification
Substance Listed:
EINECS (European INventory of Existing Commercial chemical Substances) List

Hazard classification & labelling

Warning! According to the harmonised classification and labelling (CLP00) approved by the European Union, this substance causes serious eye irritation, causes skin irritation and may cause an allergic skin reaction.

Additionally, the classification provided by companies to ECHA in REACH registrations identifies that this substance is toxic to aquatic life with long lasting effects.

Breakdown of all 918 C&L notifications submitted to ECHA

Eye Irrit. 2 H319 Harmonised Classification
Skin Irrit. 2 H315 Harmonised Classification
Skin Sens. 1 H317 Harmonised Classification
Aquatic Chronic 2 H411
Aquatic Acute 1 H400
Aquatic Chronic 3 H412
Water-react. 3 H261
Not Classified
0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100%

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/tick.png Harmonised Classification

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/Reach.png REACH registration dossiers notifications

https://echa.europa.eu/diss-blank-theme/images/cnl/graph/CLP.png CLP notifications

Properties of concern

  • Ss
Officially recognised in the EU as Skin sensitising ( Harmonised C&L).
  • Ss
There is broad agreement in that a majority of data submitters agree this substance is Skin sensitising (100% of REACH registrations).

Regulatory context

Registration, Evaluation, Authorisation & Restriction of Chemicals (REACH)

Registration
Pre-registration:
Substance pre-registered under REACH.
Registration:
This substance has 2 active registrations under REACH, 1 Joint Submission(s) and 0 Individual Submission(s).
Please see Registrants/Suppliers details.
Evaluation
Dossier Evaluation:
Substance Evaluation:
Substance included in the Community Rolling Action Plan (CoRAP).
Authorisation
Candidate List:
Annex XIV (Authorisation List):
Restriction
Annex XVII (Restriction List):

Persistent Organic Pollutants Regulation (POPs)

List of substances subject to the POPs Regulation:
List of substances proposed as POPs:

Classification Labelling & Packaging (CLP)

Harmonised C&L:
A European Union Harmonised Classification & Labelling has been assigned to this substance.
Seveso Annex I:
Notified C&L:
Classification & Labelling has been notified by industry to ECHA for this substance.

Biocidal Products Regulation (BPR)

Active Substance:
Biocidal Products:

Prior Informed Consent (PIC)

Annex I:
Annex V:

European Union Observatory for Nanomaterials (EUON)

EUON:

About this substance

This substance is registered under the REACH Regulation and is manufactured in and / or imported to the European Economic Area, at ≥ 10 to < 100 tonnes per annum.

This substance is used by consumers, by professional workers (widespread uses), in formulation or re-packing and at industrial sites.

This substance is used in the following products: adhesives and sealants, coating products and fillers, putties, plasters, modelling clay.

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no public registered data indicating whether or into which articles the substance might have been processed.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: transfer of chemicals, roller or brushing applications, non-industrial spraying, treatment of articles by dipping and pouring, hand mixing with intimate contact only with personal protective equipment available and high energy work-up of substances bound in materials or articles (e.g. hot rolling/forming, grinding, mechanical cutting, drilling or sanding).

Other release to the environment of this substance is likely to occur from: indoor use and outdoor use resulting in inclusion into or onto a materials (e.g. binding agent in paints and coatings or adhesives).

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

This substance is used in the following activities or processes at workplace: closed batch processing in synthesis or formulation, batch processing in synthesis or formulation with opportunity for exposure, transfer of chemicals at dedicated facilities and transfer of substance into small containers.

Release to the environment of this substance can occur from industrial use: formulation of mixtures.

ECHA has no public registered data indicating whether or in which chemical products the substance might be used.

ECHA has no public registered data on the types of manufacture using this substance.

This substance is used in the following activities or processes at workplace: closed processes with no likelihood of exposure, closed, continuous processes with occasional controlled exposure, closed batch processing in synthesis or formulation and transfer of chemicals at dedicated facilities.

Release to the environment of this substance can occur from industrial use: in processing aids at industrial sites and as an intermediate step in further manufacturing of another substance (use of intermediates).

ECHA has no public registered data on the use of this substance in activities or processes at the workplace.

ECHA has no public registered data on the routes by which this substance is most likely to be released to the environment.

ECHA has no data from registration dossiers on the precautionary measures for using this substance. Guidance on the safe use of the substance provided by manufacturers and importers of this substance.

Registrants/suppliers

  • Intertek Deutschland GmbH_NATC, Stangenstr.1 70771 Leinfelden-Echterdingen Germany
  • SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium

Substance names and other identifiers

2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane
EC Inventory, REACH pre-registration
2,2-bis(4-hydroxyphenyl)propane bis(2,3-epoxypropyl) ether
FCM and Articles Regulation, Annex I - Authorised Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use
bis-[4-(2,3-epoxipropoxi)phenyl]propane
C&L Inventory, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, General Product Safety Directive - Hazardous Substances, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
Bisphenol A diglycidyl ether
Other
2,2-bis(p-(2,3-epoxipropoxi)phenyl]propan (da)
C&L Inventory
2,2-bis-[4-(2,3-epossipropossi)fenil]-propano (it)
C&L Inventory
2,2-bis-[4-(2,3-epoxipropoxi)fenil]propano (es)
C&L Inventory
2,2-bis[4(2,3-epoxypropoxy)fenyl]-propaan (nl)
C&L Inventory
2,2-bis[4-(2,3-epoksypropoksy)fenyl]propan (no)
C&L Inventory
2,2-bis[4-(2,3-epoksypropoksy)fenylo]propan (pl)
C&L Inventory
2,2-bis[4-(2,3-epoxipropoxi)fenyl]propan (sv)
C&L Inventory
2,2-bis[4-(oxiranylmetoxy)fenyl]propán (sk)
C&L Inventory
2,2’-[(1-metiletilidén)bisz(4,1-fenilénoximetilén)]biszoxirán (hu)
C&L Inventory
4,4'-Methylen diphenyldiglycidylether (de)
C&L Inventory
Bis(4,4'-glycidyloxyphenyl)-propan (de)
C&L Inventory
bis-[4-(2,3-epoksipropoksi)felil]propanas (lt)
C&L Inventory
bis-[4-(2,3-epoksipropoksi)fenil]propan (hr)
C&L Inventory
bis-[4-(2,3-epoksipropoksi)fenil]propāns (lv)
C&L Inventory
bis-[4-(2,3-epoxipropoxi)fenil]propan (ro)
C&L Inventory
bis-[4-(2,3-époxypropoxy)phényl]propane (fr)
C&L Inventory
bis[4,4'-bis(glicidiloksi)fenil]propan (sl)
C&L Inventory
bis[4-(2,3-Epoksipropoksi)fenyyli]propaani (fi)
C&L Inventory
bis[4-(2,3-Epoksüpropoksü)fenüül]propaan (et)
C&L Inventory
bis[4-(2,3-epoxypropoxy)fenyl]propan (cs)
C&L Inventory
bisfenol A diglycidyleter (no)
C&L Inventory
bisphenol-A-diglycidylether (da)
C&L Inventory
éther diglycidique du bisphénol A (fr)
C&L Inventory
бис[4-(2,3-епоксипропокси)фенил]пропан (bg)
C&L Inventory
Oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis-
Other
2,2' (1 methylethylidene) bis (4,1-phenyleneoxymethylene) bisoxirane
C&L Inventory
2,2'-[propane-2,2-diylbis(4,1-phenyleneoxymethylene)]dioxirane
C&L Inventory, Registration dossier
2,2-Bis(4-glycidyloxyphenyl)propane
C&L Inventory
2-(4-{2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl}phenoxymethyl)oxirane
C&L Inventory
2-[[4-[2-[4-(oxiran-2-ylmethoxy) phenyl]propan-2-yl]phenoxy]methyl]oxirane
C&L Inventory
2-[[4-[2-[4-(oxiran-2-ylmethoxy)phenyl]propan-2-yl]phenoxy]methyl]oxirane
C&L Inventory, Other
2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2-yl)phenoxy]methyl}oxirane
Other
4,4'-Isopropylidenediphenol, oligomeric reaction products with 1-chloro-2,3-epoxypropane
Registration dossier
4,4'-Methylendiphenyldiglycidylether
C&L Inventory
BADGE
Registration dossier
Bis[4-(2,3-epoxy propoxy) phenyl] propane
C&L Inventory
bis[4-(2,3-EPOXYPROPOXY)PHENYL]PROPANE
C&L Inventory
bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700)
Registration dossier
DER 332 Epoxy Resin
C&L Inventory
DIGLYCIDYL ETHER OF BISPHENOL A
C&L Inventory
Public name: reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700)
Registration dossier
Reaction mass of meso-2-{ [4-(2-{ 4-[(oxiran-2-yl)methoxy]phenyl} propan-2-yl)phenoxy]methyl} oxirane and (2RS)-2-({ 4-[2-(4-{ [(2RS)-oxiran-2-yl]methoxy} phenyl)propan-2-yl]phenoxy} methyl)oxirane
Registration dossier
reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight <= 700)
Registration dossier
reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight <=700)
Registration dossier
Reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700)
Registration dossier
Reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700) (BADGE)
Registration dossier
Reaction product: bisphenol-A-(epichlorhydrin); epoxy resin (number average molecular weight ≤ 700), or 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bisoxirane, or Oxirane, 2,2'-[(1-methylethylidene)bis(4,1-phenyleneoxymethylene)]bis
Registration dossier
2-(chloromethyl)oxirane; 4-[2-(4-hydroxyphenyl)propan-2-yl]phenol
Registration dossier
D.E.R.(TM) 330 Liquid Epoxy Resin
Registration dossier
D.E.R.(TM) 331 Liquid Epoxy Resin
Registration dossier
D.E.R.(TM) 331(TM) Liquid Epoxy Resin
Registration dossier
D.E.R.(TM) 331P Liquid Epoxy Resin
Registration dossier
D.E.R.(TM) 332 Liquid Epoxy Resin
Registration dossier
D.E.R.(TM) 337 Semi-solid Epoxy Resin
Registration dossier
D.E.R.(TM) 383 Liquid Epoxy Resin
Registration dossier
DGEBA
Registration dossier
EC01
Registration dossier
EPICLON 840
Registration dossier
EPICLON 840-LV
Registration dossier
EPICLON 840-S
Registration dossier
EPICLON 840-SS
Registration dossier
EPICLON 850
Registration dossier
EPICLON 850-CRP
Registration dossier
EPICLON 850-LC
Registration dossier
EPICLON 850-S
Registration dossier
EPIDIAN 4
Registration dossier
EPIDIAN 4R
Registration dossier
EPIDIAN 4S
Registration dossier
EPIDIAN 5
Registration dossier
EPIDIAN 5S
Registration dossier
EPIDIAN 6
Registration dossier
EPIDIAN 6D
Registration dossier
EPIDIAN 6R
Registration dossier
EPIDIAN 6S
Registration dossier
EPIDIAN 6SD
Registration dossier
EPIKOTE(TM) 828-LVEL
Registration dossier
Epilox A 17-01
Registration dossier
Epilox A 18-00
Registration dossier
Epilox A 19-00
Registration dossier
Epilox A 19-02
Registration dossier
Epilox A 19-03
Registration dossier
Epilox A 19-04
Registration dossier
Epilox A 25-02
Registration dossier
Epilox A 32-02
Registration dossier
Epilox M 600
Registration dossier
Epilox M 631
Registration dossier
Epoxy resin
Registration dossier
GY 2600
Registration dossier
jER827
Registration dossier
jER828
Registration dossier
jER828EL
Registration dossier
jER828P
Registration dossier
jER828US
Registration dossier
jERYL6810
Registration dossier
Lapox AR-101
Registration dossier
Lapox-B-11
Registration dossier
Phenol, 4,4'-(1-methylethylidene)bis-, polymer with (chloromethyl)oxirane
Registration dossier
RAZEEN LR (any other numbers)
Registration dossier
RAZEEN LR 1100
Registration dossier
RAZEEN LR 1150
Registration dossier
Reaction mass of meso-2-{[4-(2-{4-[(oxiran-2-yl)methoxy]phenyl}propan-2yl)phenoxy]methyl}oxirane and (2RS)-2-({4-[2-(4-{[(2RS)-oxiran-2yl]methoxy}phenyl)propan-2-yl]phenoxy}methyl)oxirane
Registration dossier
Technical bisphenol a diglycidyl ether
Registration dossier
YD-128
Registration dossier
1018476-17-9
CAS number
Other
116161-20-7
CAS number
Other
1226906-55-3
CAS number
Other
1253646-32-0
CAS number
Other
1416960-74-1
CAS number
Other
1608493-63-5
CAS number
Other
1645304-11-5
CAS number
Other
1675-54-3
CAS number
EC Inventory, C&L Inventory, Registration dossier, REACH pre-registration, Other, CAD - Chemical Agents Directive, Art. 2(b)(i) - Hazardous Agents, Construction Product Regulation - Annex I (3) - Hazardous Substances, Construction Product Regulation - Art. 6(5) - SDS and Declaration, EU Ecolabels - Restrictions for Hazardous Substances/Mixtures, Active Implantable Medical Devices Directive - Hazardous Substances, In Vitro Diagnostic Medical Devices Directive - Hazardous Substances, Marine Environmental Policy Framework Directive - Hazardous Substances, Medical Devices Directive - Hazardous Substances, FCM and Articles Regulation, Annex I - Authorised Substances, General Product Safety Directive - Hazardous Substances, FCMs Recycled Plastic & Articles Regulation - Annex I - Authorised Use, Workplace Signs - minimum requirements & signs on containers and pipes, Safety and Health of Workers at Work Directive - Hazardous Substances, Waste Framework Directive, Annex III - Waste - Hazardous Properties, Physical, Biological and Chemical Agents & Processes and Work
170962-54-6
CAS number
Other
1826890-03-2
CAS number
Other
1826890-16-7
CAS number
Other
1886013-38-2
CAS number
Other
1889329-63-8
CAS number
Other
220756-60-5
CAS number
Other
47424-12-4
CAS number
Other
603-073-00-2
Index number
C&L Inventory
64339-51-1
CAS number
Other
85101-00-4
CAS number
Other

Scientific properties

Physical and chemical properties

This section provides physicochemical information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Appearance/physical state / colour

Data not provided by the registrant

Melting/freezing point

Data not provided by the registrant

Boiling point

Data not provided by the registrant

Density

Data not provided by the registrant

Vapour pressure

Data not provided by the registrant

Partition coefficient

Data not provided by the registrant

Water solubility

Data not provided by the registrant

Solubility in organic solvents / fat solubility

Data not provided by the registrant

Surface tension

Data not provided by the registrant

Flash point

Data not provided by the registrant

Auto flammability

Data not provided by the registrant

Flammability

Data not provided by the registrant

Explosiveness

Data not provided by the registrant

Oxidising

Data not provided by the registrant

Oxidation reduction potential

Data not provided by the registrant

pH

Data not provided by the registrant

Dissociation constant

Data not provided by the registrant

Viscosity

Data not provided by the registrant

Environmental fate and pathways

This section provides environmental fate and pathways information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Phototransformation in air

Data not provided by the registrant

Hydrolysis

Data not provided by the registrant

Phototransformation in water

Data not provided by the registrant

Phototransformation in soil

Data not provided by the registrant

Biodegradation in water - screening tests

Data not provided by the registrant

Biodegradation in water & sediment - simulation tests

Data not provided by the registrant

Biodegradation in soil

Data not provided by the registrant

Bioaccumulation: aquatic / sediment

Data not provided by the registrant

Bioaccumulation: terrestrial

Data not provided by the registrant

Adsorption/desorption

Data not provided by the registrant

Henrys law constant (H)

Data not provided by the registrant

Distribution modelling

Data not provided by the registrant

Ecotoxicological information

This section provides ecotoxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Predicted No-Effect Concentration (PNEC)

Data not provided by the registrant

Short–term toxicity to fish

Data not provided by the registrant

Long–term toxicity to fish

Data not provided by the registrant

Short–term toxicity to aquatic invertebrates

Data not provided by the registrant

Long–term toxicity to aquatic invertebrates

Data not provided by the registrant

Toxicity to aquatic algae and cyanobacteria

Data not provided by the registrant

Toxicity to aquatic plants other than algae

Data not provided by the registrant

Toxicity to microorganisms

Data not provided by the registrant

Sediment toxicity

Data not provided by the registrant

Endocrine disrupter testing in aquatic vertebrates – in vivo

Data not provided by the registrant

Toxicity to terrestrial macroorganisms except arthropods

Data not provided by the registrant

Toxicity to terrestrial arthropods

Data not provided by the registrant

Toxicity to terrestrial plants

Data not provided by the registrant

Toxicity to soil microorganisms

Data not provided by the registrant

Toxicity to birds

Data not provided by the registrant

Toxicity to mammals

Data not provided by the registrant

Toxicological information

This section provides toxicological information compiled from all automatically processable data from REACH registration dossiers that is available to ECHA at the time of generation. The quality and correctness of the information remains the responsibility of the data submitter. The Agency thus cannot guarantee the correctness of the information displayed.

Derived No- or Minimal Effect Level (DN(M)EL)

Data not provided by the registrant

Toxicokinetics, metabolism, and distribution

Data not provided by the registrant

Acute toxicity

Data not provided by the registrant

Irritation / corrosion

Data not provided by the registrant

Sensitisation

Data not provided by the registrant

Repeated dose toxicity

Data not provided by the registrant

Genetic toxicity

Data not provided by the registrant

Carcinogenicity

Data not provided by the registrant

Toxicity to reproduction

Data not provided by the registrant

Neurotoxicity

Data not provided by the registrant

Immunotoxicity

Data not provided by the registrant

Endocrine disrupter mammalian screening - in vivo

Data not provided by the registrant