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EC number: 413-110-2 | CAS number: 135861-56-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Experimental data on toxicokinetics are not available. The substance has a molecular weight of 414 and an experimentally determined log Pow of 3.4. The solubility is very low. Based on that it is forecasted that this substance won't be uptaken by the body. This is consistent with the general absence of findings in the acute and chronic toxicity studies.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
The following remarks on the toxicokinetics of the substance are based on the following physicochemical properties of the substance:
Molecular weight: 414.5
Water solubility: 0.00004 mg/L (<0.1 mg/L)
Partition coefficient log Kow: 3.4
Experimental toxicokinetic studies were not available.
ABSORPTION
The molecular mass of the substance molecular mass (414.5) suggest that the absorption from the gastro-intestinal tract subsequent to oral ingestion could be possible. However the log Kow = 3.4 suggests that the potential for absorption is low.
In the repeated studies done of oral exposure 28 days and 90 days, these assumptions are confirmed and the oral absorption is confirmed to be nul or low, because no effects are seen in different organs evaluated.
Molecular weight of the substance could favour dermal absorption, but log Kow=3.4 doesn't. Results on repeated dose by dermal route are not available. However the controls done in the acute dermal toxicity determination shows no effects on organs which allow to think that the the absorption is low or nul.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution is expected. But this assumption is not confirmed because there aren't any changes shown in the repeated dose toxicity studies following oral application. If it is considered that the absorption of the substance is low, it is not expected to find the molecule distributed into the organs.
There is no information available of the metabolism of this substance.
ELIMINATION
The n-Octanol/water partition coefficient (log Pow of 3.4) and the low solubility allow to forecast that this substance won't be uptaken by the body and will be eliminated by the body. This is consistent with the general absence of findings in the acute and chronic toxicity studies. Only one study showed systemic findings which may be treatment related. Therefore no potential for bioaccumulation is to be expected.
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