(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Endpoint summary

Description of key information

Experimental data on toxicokinetics are not available. The substance has a molecular weight of 414 and an experimentally determined log Pow of 3.4. The solubility is very low. Based on that it is forecasted that this substance won't be uptaken by the body. This is consistent with the general absence of findings in the acute and chronic toxicity studies. 

Key value for chemical safety assessment

Bioaccumulation potential:

no bioaccumulation potential

Absorption rate - oral (%):

50

Absorption rate - dermal (%):

50

Absorption rate - inhalation (%):

100

Additional information

The following remarks on the toxicokinetics of the substance are based on the following physicochemical properties of the substance:

Molecular weight: 414.5

Water solubility: 0.00004 mg/L (<0.1 mg/L)

Partition coefficient log Kow: 3.4

Experimental toxicokinetic studies were not available.

 

ABSORPTION

The molecular mass of the substance molecular mass (414.5) suggest that the absorption from the gastro-intestinal tract subsequent to oral ingestion could be possible. However the log Kow = 3.4 suggests that the potential for absorption is low.

In the repeated studies done of oral exposure 28 days and 90 days, these assumptions are confirmed and the oral absorption is confirmed to be nul or low, because no effects are seen in different organs evaluated.

Molecular weight of the substance could favour dermal absorption, but log Kow=3.4 doesn't. Results on repeated dose by dermal route are not available. However the controls done in the acute dermal toxicity determination shows no effects on organs which allow to think that the the absorption is low or nul.

DISTRIBUTION and METABOLISM

As a small molecule a wide distribution is expected. But this assumption is not confirmed because there aren't any changes shown in the repeated dose toxicity studies following oral application. If it is considered that the absorption of the substance is low, it is not expected to find the molecule distributed into the organs.

There is no information available of the metabolism of this substance.

 

ELIMINATION

The n-Octanol/water partition coefficient (log Pow of 3.4) and the low solubility allow to forecast that this substance won't be uptaken by the body and will be eliminated by the body. This is consistent with the general absence of findings in the acute and chronic toxicity studies. Only one study showed systemic findings which may be treatment related. Therefore no potential for bioaccumulation is to be expected.