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EC number: 413-110-2
CAS number: 135861-56-2
Experimental data on toxicokinetics are not available. The substance has a molecular weight of 414 and an experimentally determined log Pow of 3.4. The solubility is very low. Based on that it is forecasted that this substance won't be uptaken by the body. This is consistent with the general absence of findings in the acute and chronic toxicity studies.
The following remarks on the toxicokinetics of the substance are based
on the following physicochemical properties of the substance:
Molecular weight: 414.5
Water solubility: 0.00004 mg/L (<0.1 mg/L)
Partition coefficient log Kow: 3.4
Experimental toxicokinetic studies were not available.
The molecular mass of the substance molecular mass (414.5) suggest that
the absorption from the gastro-intestinal tract subsequent
to oral ingestion could be possible. However the log Kow = 3.4 suggests
that the potential for absorption is low.
In the repeated studies done of oral exposure 28 days and 90 days, these
assumptions are confirmed and the oral absorption is confirmed to be nul
or low, because no effects are seen in different organs evaluated.
Molecular weight of the substance could favour dermal absorption, but
log Kow=3.4 doesn't. Results on repeated dose by dermal route are not
available. However the controls done in the acute dermal toxicity
determination shows no effects on organs which allow to think that the
the absorption is low or nul.
DISTRIBUTION and METABOLISM
As a small molecule a wide distribution is expected. But this assumption
is not confirmed because there aren't any changes shown in the repeated
dose toxicity studies following oral application. If it is considered
that the absorption of the substance is low, it is not expected to find
the molecule distributed into the organs.
There is no information available of the metabolism of this substance.
The n-Octanol/water partition coefficient (log Pow of 3.4) and the low
solubility allow to forecast that this substance won't be uptaken by the
body and will be eliminated by the body. This is consistent with the
general absence of findings in the acute and chronic toxicity studies.
Only one study showed systemic findings which may be treatment related.
Therefore no potential for bioaccumulation is to be expected.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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