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EC number: 413-110-2
CAS number: 135861-56-2
Acute oral toxicity: LD50 > 5000 mg/kg bw, OECD Guideline 401Acute dermal toxicity: LD50 > 2000 mg/kg bw, OECD Guideline 402
This substance has been investigated in two
acute oral toxicity studies and two acute dermal studies. All studies
consistently show absence of mortality and target organ toxicity. All
studies were performed according to GLP and OECD guidelines.
For acute oral toxicity, the two studies
available were performed with doses of up to 5000 mg/kg bw studied with
male and female rats of different strains (Albino rats and Crl CDBR).
The test animals were feeded with the substance in oral gavage. No
mortality and no treatment-related clinical signs were recorded in any
of the two studies. As a conclusion, acute oral toxicity is therefore
For acute dermal toxicity, the two studies
available were performed with rats (Sprague Dawley). In both studies,
the substance was appliead in a semi-occlusive coverage with vehicles
liquid paraffine and arachis oil respectively. The substance applied was
2000 mg/kg and after the observation period of 24h there was no
mortality, no clinical signs and no effect on body weight gain. Any
dermal effects were observed during the treatment or after. As a
conclusion, acute dermal toxicity is therefore considered low.
The available experimental test data are
reliable and suitable for classification purposes under Regulation
1272/2008. The values obtained have been compared to the limit values as
stated in the Annex I of the Regulation (table 3.1.1.). As a result the
substance is not considered to be classified for acute toxicity under
Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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