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Diss Factsheets
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EC number: 204-337-6 | CAS number: 119-61-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Key studies: Based on available studies performed with benzophenone where it was determined to be negative (two in-vitro studies on mutation reverse bacterial assay (test method equivalent to 471), a gene mutation in mammalian cells (test method equivalent to OECD 476), and two in-vivo micronucleous studies in bone marrow and peripheral blood), benzophenone is considered to be non-genotoxic.
Supporting studies:
In a study performed according to a new bacterial reversion assay, the WP2 Mutoxitest, which is used for the detection of oxidative mutagenicity in E.coli, the test substance was determined to be negative under the test conditions.
In a SOS/umu test, benzophenone induced umu gene expression after metabolic activation by recombinant human cytochrome P450s. Negative results were obtained in the presence or absence of human, rat or mouse liver microsomes.
In a DNA damage/repair test, the test item did not reveal a positive result since no DNA repair was detected in the DNA polymerase-deficient mutant of E. coli strains.
Benzophenone was negative in the in-vivo flow cytometer-based micronucleus assay in mouse since no increase in the frequencies of micronucleated polychromatic erythrocytes was found in the peripheral blood.
Justification for selection of genetic toxicity endpoint
No study was selected since all the studies were negative.
Short description of key information:
Key study: Equivalent to OECD 471. Test item was negative.
Key study: Equivalent to OECD 471. Test item was negative.
Key study: Equivalent to OECD 476. Test item was negative.
Key study: Equivalent to OECD 474. Test item was negative.
Key study. Equivalent to OECD 474. Test item was negative.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.