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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vivo
Remarks:
Type of genotoxicity: other: in vivo: DNA binding assay and DNA covalent binding in mouse liver
Type of information:
other:
Adequacy of study:
supporting study
Study period:
2012
Rationale for reliability incl. deficiencies:
other: Short description on comprehensive studies available via the internet by US EPA and pubchem.ncbi.nlm.nih.gov

Data source

Reference
Reference Type:
secondary source
Title:
lactofen - Compound Summary (CID 62276)
Author:
US EPA and Pubchem NCBI
Year:
2012
Bibliographic source:
http://iaspub.epa.gov/apex/pesticides/f?p=chemicalsearch:3:0::no:1,3,31,7,12,25:p3_xchemical_id:2666

Materials and methods

Principles of method if other than guideline:
short summary on different studies
Type of assay:
other: In vitro: Salmonella typhimurium/mammalian microsome mutagenicity assay, mammalian cytogenetic assay and unscheduled DNA synthesis,

Test material

Constituent 1
Chemical structure
Reference substance name:
(2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
EC Number:
616-466-9
Cas Number:
77501-63-4
Molecular formula:
C19H15ClF3NO7
IUPAC Name:
(2-ethoxy-1-methyl-2-oxoethyl)-5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate
Test material form:
not specified
Details on test material:
no data

Test animals

Species:
other: short summary on different experiments
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: in vitro / in vivo studies

Examinations

Tissues and cell types examined:
see summary

Results and discussion

Any other information on results incl. tables

The guideline and non-guideline studies indicate that lactofen is neither genotoxic nor mutagenic.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): negative
Executive summary:

Executive summary is derived from the following internet links on 2012 -11 -09.

http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=62276#x321

http://www.epa.gov/iris/subst/0280.htm

References of individual studies:

PPG Industries. 1985b. MRID No. 00132883, 00150329. Available from EPA. Write to FOI, EPA, Washington, DC 20460.

• /GENOTOXICITY/ The guideline and non-guideline studies indicate that lactofen is neither genotoxic nor mutagenic. Equivocal (probably negative) results were observed in an in vivo DNA binding assay with radiolabeled lactofen. Salmonella typhimurium/mammalian microsome mutagenicity assay: negative with and without S-9. In vitro cytogenetic assay with Chinese hamster ovary (CHO) cells: negative for clastogenic effects with and without S-9. In vitro unscheduled DNA synthesis in primary mouse and rat hepatocytes: negative. In vivo DNA covalent binding in mouse liver: low level of binding (equivocal, probably negative).