Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
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EC number: 218-491-7 | CAS number: 2163-00-0
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented.
Data source
Reference
- Reference Type:
- publication
- Title:
- no data
- Author:
- Selan, F. M.; Evans, M. A.
- Year:
- 1 987
- Bibliographic source:
- Res. Commun. Chem. Pathol.|Pharmacol., vol. 55, 249-269
Materials and methods
- Type of study / information:
- Effect on hepatic triglyceride secretion in vitro
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The concentration which would inhibit Triglyceride secretion by 50 % (IC50) in freshly isolated rat hepatocytes was determined for the test substance by the method of least squares. The IC50 values were calculated by linear regression analysis of the linear portion of the triglyceride secretion data.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,6-dichlorohexane
- EC Number:
- 218-491-7
- EC Name:
- 1,6-dichlorohexane
- Cas Number:
- 2163-00-0
- Molecular formula:
- C6H12Cl2
- IUPAC Name:
- 1,6-dichlorohexane
- Test material form:
- not specified
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- IC50 for triglyceride secretion by isolated rat hepatocytes determined for 1,6-dichlorohexane = 1.4 +- 0.3 mg/mL.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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