Registration Dossier
Registration Dossier
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EC number: 218-491-7 | CAS number: 2163-00-0
Endpoint summary
Administrative data
Description of key information
Additional information
The study on the bioaccumulation in aquatic species preferably fish was waived as its performance is scientifically not justified. Regulation (EC) No 1907/2006 (Annex IX, sect. 9.3.2, column 2) states as follows:
"The study need not be conducted if:
- the substance has a low potential for bioaccumulation (for instance a log Kow <= 3) and/or a low potential to cross biological membranes, or
- direct and indirect exposure of the aquatic environment is unlikely.”
Based on RMMs and OCs implemented, exposure of the test item to water is highly unlikely.
Furthermore, the substance is very volatile. Consequently, the exposure of the test item to water is very low.
Further, using EPIWIN 4.1 software and the ACD/Log D Suite program for 1,6-dichlorohexane a bioconcentration factor (BCF) of 103.3 L/Kg wwt, indicating a low bioaccumulation potential.
In addition, a Mackay level I calculation gives the general impression of the likely media into which the test substance 1,6-dichlorhexanewill tend to partition and an indication of relative concentrations in each medium and compartment, respectively. Low concentrations in aquatic compartment and also in fish were calculated. Thus, a low bioaccumulation potential of the substance is expected.
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