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EC number: 211-989-5
CAS number: 732-26-3
Table 1: Summary of Mortality data in the 2000 mg/kg
bw Dose Group
Survived until scheduled necropsy
Killed in extremis on day 4 after dosing
Killed in extremis on day 1 after dosing
Found dead on day 1 after dosing
The acute toxicity potential of the test material was investigated in a
study conducted in accordance with the standardised guidelines OECD 401
and EU Method B.1 under GLP conditions.
A group of ten fasted Sprague-Dawley rats (five males and five females)
was given a single oral dose of the test material as a suspension in
arachis oil B.P. at a dose level of 2000 mg/kg bodyweight. An additional
group of ten fasted animals was then treated with the test material
administered as a suspension in arachis oil B.P. a t a dose level of 200
mg/kg bodyweight. The surviving animals were observed for fourteen days.
All animals were subjected to a gross pathological examination.
Two females treated with 2000 mg/kg were found dead one day after
dosing. Four animals (one male and three females) in this group were
killed in extremis one or four days after dosing. Common signs of
systemic toxicity noted in this group were ataxia, hunched posture,
lethargy, decreased respiratory rate and laboured respiration with
additional signs of ptosis and loss of righting reflex. Surviving
animals in this group recovered three or ten days after dosing. There
were no deaths or signs of systemic toxicity noted in animals treated
with 200 mg/kg.
One male treated with 2000 mg/kg showed a slightly reduced gain in
bodyweight during week one. All other surviving animals showed the
expected gain in bodyweight during the study.
Abnormalities noted at necropsy of animals that died or were killed in
extremis during the study were haemorrhagic lungs, dark or pale liver,
patchy pallor of the liver or red-coloured possible necrosis of the
liver and haemorrhagic or pale gastric mucosa. No abnormalities were
noted at necropsy of one female treated with 2000 mg/kg that was killed
in extremis during the study, four males treated with 2000 mg/kg and
animals treated with 200 mg/kg that were sacrificed at the end of the
Under the conditions of this study the LD50 was found to be greater than
200 mg/kg bw but less than 2000 mg/kg bw.
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