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EC number: 211-989-5
CAS number: 732-26-3
Table 1: Body Weights (g)
Sex / Dose Level
Males / 2000
Females / 2000
The potential of the test material to cause acute dermal toxicity in the
rat was investigated in accordance with the standardised guidelines OECD
402, EU Method B.3, US EPA OPPTS 870.1200 and JMAFF 12 Nousan,
Notification No 8147 under GLP conditions.
The test material was administered to five Wistar rats of each sex by a
single dermal application in an occlusive fashion at a limit dose of
2000 mg/kg body weight for 24 hours. After the exposure period,
dressings were removed and the skin cleaned of residual test material
using tap water. Animals were subjected to daily observations and weekly
determination of body weight. Macroscopic examination was performed
after terminal sacrifice (Day 15). No mortality occurred and there were
no clinical signs noted for the animals. However, general erythema was
noted for one female animal on Day 2. The changes noted in body weight
gain in males and females were within the range expected for rats used
in this type of study and were therefore considered not indicative of
No abnormalities were found at macroscopic post mortem examination of
Under the conditions of this study the LD50 value was found to exceed
2000 mg/kg bw.
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