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EC number: 470-080-3
CAS number: -
In an in vivo eye irritation test according
to OECD 405 (GLP), an amount of 0.1 mL bulk volume (about 26 mg) of the
test substance (purity: 93.0 weight-%) was applied to one eye of three
White New Zealand rabbits (stepwise procedure starting with one animal
and supplementing two additional animals). About 1 hours after
application the eye was rinsed with tap water. The ocular reactions were
assessed approximately 1, 24, 48 and 72 hours after application.
Slight or moderate conjunctival redness,
slight conjunctival chemosis and slight discharge were observed in the
animals during the observation period. In addition, injected scleral
vessels in a circumscribed area were noted in a single animal after 1
hour, only. The ocular reactions were reversible. One animal had
recovered by 24 hours (all scores "0" for cornea, iris and conjunctiva).
A second animal had recovered by 48 hours, and the third by 72 hours.
Mean scores calculated for each animal over 24, 48 and 72 h were 0.0 for
corneal opacity and for iris lesions,1.0/0.3/0.0 for redness of the
conjunctiva and 0.3/0.0/0.0 for chemosis.
Considering the described ocular reactions
as well as the average score for irritation,
does not show an eye irritation potential under the test conditions
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