Reaction products of Soya and Linseed Oil Fatty Acids with Bisphenol A diglycidylether

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Justification for type of information:

REPORTING FORMAT FOR THE ANALOGUE APPROACH
This read-across hypothesis corresponds to scenario 2 of the Read-Across Assessment Framework (RAAF), ECHA, March 2017 - different compounds have qualitatively similar properties - of the read-across assessment framework i.e. properties of the target substance are predicted to be quantitatively equal to those of the source substance. Namely, the source substance BADGE predicts the toxicological and ecotoxicological properties of the target substance Soya/Linseed Oil Fatty Acid-BADGE reaction product.

1. HYPOTHESIS FOR THE ANALOGUE APPROACH
for details see Justification for read-across attached to iuclid section 13

2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
for details see Justification for read-across attached to iuclid section 13

3. ANALOGUE APPROACH JUSTIFICATION
for details see Justification for read-across attached to iuclid section 13

4. DATA MATRIX
for details see Justification for read-across attached to iuclid section 13

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across: supporting information

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 211 (Daphnia magna Reproduction Test)

Deviations:

yes

Remarks:

No clean water control, only a solvent (acetone) control included in the test design

Analytical monitoring:

no

Test organisms (species):

Daphnia magna

Test type:

semi-static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

21 d

Nominal and measured concentrations:

Nominal concentrations: 0, 0.03, 0.1, 0.3, 1, 3

Reference substance (positive control):

not specified

Duration:

21 d

Dose descriptor:

NOEC

Effect conc.:

0.3 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: survival, growth and reproduction

Remarks on result:

other: no data

Duration:

21 d

Dose descriptor:

LOEC

Effect conc.:

1 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: survival, growth and reproduction

Remarks on result:

other: no data

Validity criteria fulfilled:

yes

Remarks:

One control beaker was omitted from the anaysis as it showed lower than normal reproduction.

Conclusions:

The NOEC is 0.3 mg/L; survival, growth and reproduction were all significantly reduced at 1 mg/L.

Executive summary:

D. magna were exposed to five concentrations of Epikote 828 ranging from 0.03 - 3 mg/L and control dilution water for 21 days in a static renewal test design. Survival, growth, and reproduction rate were all significantly reduced at 1 mg/L of Epikote 828, but were all unaffected at 0.3 mg/L.

Description of key information

21-day NOEC = 0.3 mg/L (similar to OECD TG 2011, Daphnia magna; read-across: BADGE)

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

0.3 mg/L

Additional information

No experimental data are available for the target substance Soya/Linseed Oil Fatty Acid-BADGE. However, a reliable Daphnia reproduction study is available for the source substance BADGE. A justification for read-across is attached to iuclid section 13.

 

A long term test with Daphnia magna similar to OECD TG 211 was conducted with BADGE. This test was deemed reliable and useful for risk assessment (Klimish score = 2). In this test, D. magna were exposed to five concentrations of the test item ranging from 0.03 - 3 mg/L and control dilution water for 21 days in a static renewal test design. Survival, growth, and reproduction rate were all significantly reduced at 1 mg/L, but were all unaffected at 0.3 mg/L.