Registration Dossier
Registration Dossier
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EC number: 244-848-1 | CAS number: 22224-92-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1999-09-17 to 2000-03-03
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 368 mg/L
- Conc. based on:
- test mat.
- Incubation duration:
- >= 0.5 - <= 24 h
- Temp.:
- 20 °C
- pH:
- >= 5 - <= 7
- Conclusions:
- The water solubility of the test item was determined to be 368 mg/L in unbuffered aqueous solution at 20 °C.
- Executive summary:
The water solubility of the test item was determined in an experimental study according to OECD Test Guideline 105 and EU Method A.6. The water solubility was determined at pH 4, pH 7, pH 9 and in unbuffered water. No influence of the pH or the stirring time could be detected. The water solubility of the test item was determined to be 368 mg/L in unbuffered aqueous solution at 20 °C.
Reference
Water solubility - Calculation of results
| acidic | neutral | pH 5.5 - 7 | alkaline |
| Citrate buffer adjusted to pH 4 with cone, sodium hydroxide | Phosphate buffer adjusted to pH 7 with cone. H3PO4 | unbuffered water in equilibrium with atmospheric carbon dioxide | borate buffer |
pH | 4 | 7 | (5 – 7) | 9 |
(measured) | (4.03) | (6.92) | (--) | (9.20) |
| Concentration in mg / L | Concentration in mg / L | Concentration in mg / L | Concentration in mg / L |
Stirring time / h |
|
|
|
|
0.5 | 361.18 | 351.12 | 366.61 | 345.00 |
1 | 353.22 | 342.03 | 364.93 | 342.57 |
2 | 358.99 | 341.07 | 371.77 | 345.37 |
4 | 354.42 | 348.51 | 368.67 | 342.39 |
8 | 352.22 | 343.70 | 371.06 | (360.14) |
24 / 105 |
|
| 364.84 | 344.87 |
Mean | 356.01 | 345.29 | 367.98 | 344.04 |
R.S.D. | 1.09 % | 1.26 % | 0.82 % | 0.42 % |
The means from the results performed for each pH are summarized in the table given above. It becomes evident that there is no significant dependence on the stirring time showing that the solubility equilibrium was reached in all cases. By comparing the results from different series and considering the scope of the analytical error, it becomes evident, that there is no influence of the pH on the solubility between pH 4 and 9. The slight lower values found in the buffered solutions probably due to the salt in the buffer solution.
Description of key information
The water solubility of the test item was determined to be 368 mg/L in unbuffered aqueous solution at 20 °C.
Key value for chemical safety assessment
- Water solubility:
- 368 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined in an experimental study according to OECD Test Guideline 105 and EU Method A.6. The water solubility was determined at pH 4, pH 7, pH 9 and in unbuffered water. No influence of the pH or the stirring time could be detected. The water solubility of the test item was determined to be 368 mg/L in unbuffered aqueous solution at 20 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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