Registration Dossier
Registration Dossier
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EC number: 601-147-9 | CAS number: 111988-49-9
Endpoint summary
Administrative data
Description of key information
Additional information
Numerous experimental studies are available for all trophic levels investigating the short- and long-term effects of 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin on species of fish, aquatic invertebrates, algae, and microorganisms.
Short-term toxicity data are available for three trophic levels (aquatic invertebrates, fish and algae). The most sensitive species was the harlequin fly Chironomus riparius with an 48h-EC50 value of 0.0108 mg/L (nominal). Whereas in tests with different fish species sheepshead minnow (C. variegatus) was most sensitive with a determined LC50 value of 19.7 mg/L based on mean measured concentrations. In a test with green algae Pseudokirchneriella subcapitata, the EC50 for growth rate was not reached within the 72-hour test duration up to the highest test concentration of 100 mg/L (mean measured).
In long-term toxicity tests, aquatic invertebrates also showed the highest sensitivity towards 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin compared to fish and algae. In a study with harlequin fly Chironomus riparius (OECD 233), the deduced NOEC value was 0.56 µg/L (nominal) based on fertility. For fish, the 97-day key study (according to OECD 210) with freshly fertilized rainbow trout (O. mykiss) eggs exposed to six concentrations of 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin resulted in a NOEC of 244 µg/L (mean measured). The study investigating the toxicity to aquatic algae (according to OECD 201) resulted in a distinctly higher NOEC for growth rate of 32 mg/L (nominal) after 72 hours.
The key study on the toxicity to activated sludge microorganisms (ISO 8192) revealed an EC50 (30 minutes) of 6330 mg/L (nominal).
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