Registration Dossier
Registration Dossier
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EC number: 601-147-9 | CAS number: 111988-49-9
Endpoint summary
Administrative data
Description of key information
Additional information
Numerous experimental terrestrial studies are available for different trophic levels investigating the effects of 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin on soil invertebrates, plants, microorganisms and birds.
Long-term toxicity data on invertebrates are available for Eisenia fetida, Folsomia candida and Hypoaspis aculeifer.E. fetida turned out to be the most sensitive among those species. In the key study (based on OECD 222), adult earthwormswere exposed in an artificial soil (with 5 % peat content) to the nominal test concentrations of 0.2, 0.4, 0.8, 1.6, 3.2 and 6.4 mg test item/kg soil dw (corresponding to 45.2, 90.4, 181, 362, 723 and 1427 µg a.i/kg soil dw). Statistically significant different values for the number of juveniles per test vessel relative to the control were observed at the three highest test concentration of up to 6.4 mg test item/kg dry weight artificial soil. The NOEC (56 d) was therefore determined to be 0.8 mg test item/kg soil dw corresponding to 0.181 mg a.i./kg soil dw (nominal). Additional several studies were carried out to investigate the toxicity of dimethoate on adult bees and bee larvae (more details see IUCLID chapter 6.3.2). Since studies on bees are not a standard requirement under REACh, this data are not used for the further hazard and risk assessment.
Two GLP studies are available assessing the toxicity of 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin on terrestrial plants performed according to OECD 208 and EPA OPP 122 -1. No treatment related effects of observed in both studies leading to a NOEC (28 d) ≥ 64 µg a.i./kg soil dw, the lowest derived terrestrial effect value, which was used for PNEC derivation.
Two studies assessed the toxicity of the target substance on soil microorganisms. The analyzes in both studies revealed that the test item treatment had no influence on the turnover of nitrogen and soil respiration up to the highest tested concentration (NOEC (28 d)≥2.57 mg a.i./kg soil dw).
Based on the low risk for bioaccumulation of dimethoate, owing to the low Log Kow of 1.4 (pH7), there is a low concern of secondary poisoning.However, several studies investigating the toxicity of 3-(2-chlor-5-pyridyl-methyl)-cyanimino-1,3-thiazolidin
on birds are available.
The key study, which was performed according to FIFRA guideline 71-4, ASTM Standard E 1062-86, determined effects on reproduction to Mallard duck (Anas platyrhynchos). The lowest derived NOEC of parental toxicity was established at 47.6 ppm (3.75 mg a.i./kg bw/d) based on adult body weight.
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