Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 465-100-2 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
Test material
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch number: 022401
Constituent 1
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Details on sampling:
- Portions of the solutions were taken from the flasks, diluted with water to obtain concentrations within the calibration range and the
concentration of the test substance was analysed by HPLC. - Buffers:
- Buffer pH 4: 250 mL 0.1 mol/L potassium dihydrogencitrate (Fluka; Lot. No. 364546/1) and 45 mL 0.1 mol/L sodium hydroxide (Titrisol; Merck, Lot. No. OC489094) filled up to 500 mL with water.
Buffer pH 7: 250 mL 0.1 mol/L potassium dihydrogenphosphate (Merck, Lot. No. A531473427) and 148.2 mL 0.1 mol/L sodium hydroxide filled up to 500 mL with water.
Buffer pH 9: 250 mL 0.1 mol/l boric acid (Merck, Lot. No. A577065513) in 0.1 mol/L potassium chloride (Merck, Lot. No. K31517236313) and 106.5 mL 0.1 mol/L sodium hydroxide filled up to 500 mL with water. - Details on test conditions:
- The water for analysis was autoclaved before use.
- Type, material and volume of test flasks, other equipment used:
- Sterilisation method:
- Lighting:
- Measures taken to avoid photolytic effects:
- Measures to exclude oxygen:
- Details on test procedure for unstable compounds:
- Details of traps for volatile, if any
- If no traps were used, is the test system closed/open
- Is there any indication of the test material adsorbing to the walls of the test apparatus?
TEST MEDIUM
- Volume used/treatment
- Kind and purity of water:
- Preparation of test medium:
- Renewal of test solution:
- Identity and concentration of co-solvent:
OTHER TEST CONDITIONS
- Adjustment of pH:
- Dissolved oxygen:
Duration of testopen allclose all
- Duration:
- 5 d
- pH:
- 9
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.01 mol/L
- Duration:
- 5 d
- pH:
- 7
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.01 mol/L
- Duration:
- 5 d
- pH:
- 4
- Temp.:
- 50 °C
- Initial conc. measured:
- >= 0.01 mol/L
Results and discussion
- Preliminary study:
- In the preliminary test, solutions of < 50 % saturation and < 0.01 mol/L of the test substance in buffers with pH values of 4, 7 and 9 were kept at 50 °C and the concentration of "STI571 F8" was determined after various times up to a maximum of 5 days.
The preliminary test indicated that the half-lifes of the base of the test substance at 25 °C at pH 4, pH 7 and pH 9 will be greater than 1 year. Therefore the test substance is considered to be stable to hydrolysis and no main test was performed, according to the guideline. - Transformation products:
- not measured
- Remarks:
- The test substance is the hydrochloride of a base and by this the test substance dissociates in water to chloride and the protonated base. The essential part of the test substance is the base.
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- ca. 0 s-1
- DT50:
- 2 500 h
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 8 760 h
- pH:
- 7
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- ca. 0 s-1
- DT50:
- 3 060 h
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 8 760 h
- pH:
- 9
- Temp.:
- 50 °C
- Hydrolysis rate constant:
- ca. 0 s-1
- DT50:
- 3 030 h
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- > 8 760 h
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The preliminary test indicated that the half-lifes of the base of the test substance at 25 °C at pH 4, pH 7 and pH 9 will be greater than 1 year. Therefore the test substance is considered to be stable to hydrolysis .
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Although ECHA is providing a lot of online material in your language, part of this page is only in English. More about ECHA’s multilingual practice.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
the-echa-website-uses-cookies
find-out-more-on how-we-use-cookies