Registration Dossier
Registration Dossier
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EC number: 465-100-2 | CAS number: -
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Version / remarks:
- OECD Guideline No. 107 for the testing of chemicals,
adopted 27 July 1995 - Deviations:
- yes
- Remarks:
- The test substance is the hydrochloride of a base and by this the test substance dissociates in water to chloride and the protonated base. The essential part of the test substance is the base. To obtain the nondissociated base the partition coefficient sh
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
Test material
- Test material form:
- solid: particulate/powder
- Details on test material:
- Batch number: 022401
Constituent 1
- Specific details on test material used for the study:
- purity: >93 % (free base plus hydrochloride)
Free base: 79.8 %
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Key result
- Type:
- log Pow
- Partition coefficient:
- -0.51
- Temp.:
- 21 °C
- pH:
- ca. 9
Applicant's summary and conclusion
- Conclusions:
- The mean n-octanol / water partition coefficient (Pow) of the test substance is 0.308
(standard deviation = 0.015, n = 6), the mean decadic logarithm (log Pow) is -0.51.
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