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EC number: 403-140-4 | CAS number: 103694-68-4 MAJANTOL; MAJANTOL R
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19th until 23rd of October 1987
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no analytical verification, but no loss of the test substance was seen in the algae test and as well in the suporting fish study. Thus, the results based on nominal values are reliable
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Remarks:
- No loss of the test substance was seen in the algae test and as well in the suporting fish study.
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: STRAUSS
- Age at study initiation (mean and range, SD): not more than 24 hours at beginning of test
- Source: Bundesgesundheitsamt, Berlin, Germany
- Food type: The source culture is fed with fresh algae (Chlorella vulgaris) - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Total hardness of dilution water: 19.1°d
carbonate hardness of dilution water: 2.8°d - Test temperature:
- 20.3 - 20.4°C
- pH:
- 7.1 (50 mg/L) - 8.05 (1 mg/L)
- Dissolved oxygen:
- 89 - 95% oxygen concentrations
- Nominal and measured concentrations:
- Nominal concentrations: 1, 5, 10, 15, 25, 37.5, 50 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beaker
- Type (delete if not applicable): open
- Material, size, headspace, fill volume: 250 mL glass beaker, fill volume: 40 mL
- No. of organisms per vessel: 20 animals
- No. of vessels per concentration (replicates): 1
- No. of vessels per control (replicates): 1
OTHER TEST CONDITIONS
- Photoperiod: 8 hours darkness, 16 hours light - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 19 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 37.5 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- - Mortality of control:
No mortality in the control
- Immobilisation of control: No immogilisation of in the control - Reported statistics and error estimates:
- The percentage of immobilised animals at each test concentration is first calculated, and then converted to probits using the values below. These data are plotted against the log of the concentration of test substance; the linear fit is carried out by regression analysis, whereby individual points which obviously deviate from the general trend are excluded.
- Validity criteria fulfilled:
- yes
- Conclusions:
- In the acute immobilisation study with Daphnia magna according to OECD 202 an EC50(48h) of 19 mg/L was determined.
Reference
Results of the acute immobilisation test
Cumulative immobilisation at 24h and 48h, cummulative percentage of immobilisation in % ( )
Test concentrations [mg/L] |
Immobilised Daphnia [24h] |
Immobilised Daphnia [48h] |
50 |
20 (100) |
20 (100) |
37.5 |
13 (65) |
20 (100) |
25 |
6 (30) |
12 (60) |
15 |
5 (25) |
8 (40) |
10 |
2 (10) |
5 (25) |
5 |
0 (0) |
1 (5) |
1 |
0 (0) |
0 (0) |
0 (CONTROL) |
0 (0) |
0 (0) |
Description of key information
EC50(48h): 19 mg/L based on immobilisation of Daphnia magna (OECD 202, static).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 19 mg/L
Additional information
One experimental study is available investigating the short-term effects of the substance to aquatic invertebrates. The study was performed according to OECD 202 (1984) (GLP) with the water flea Daphnia magna. Nominal concentrations of 1, 5, 10, 15, 25, 37,5 and 50 mg/L were tested under static conditions. Test concentrations were not analytically verified, but the substance is expected to be stable in the test medium which was proved in the algae and fish tests. Immobilisation of D. magna was observed after 48 h resulting in an EC50 (48 h) of 19 mg/L based on nominal concentrations.
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