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EC number: 403-140-4 | CAS number: 103694-68-4 MAJANTOL; MAJANTOL R
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014-04-29
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- 3.07
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not specified
- Details on results:
- Temperature
The test temperature was measured by a data logger with an interval of 2 minutes. The mean temperature of 22.8 °C was inside the range of 20 - 25 °C ± 1 °C during the course of the study.
Signal-to-Noise
The signal-to-noise ratio for the dead time marker, reference items and the test item was > 3. - Conclusions:
- The partition coefficient log Pow of the test item was determiend to be 3.07 at 20 °C.
- Executive summary:
A study was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.8 to determine the partition coefficient of the test substance using the HPLC method. The analytical determination was conducted using a HPLC-column (e.g. C18) coupled to diode array detector (DAD). Methanol and HPLC water in a ratio of 65:35 was used as mobile phase. Calibration was performed using seven reference items with known log Pow values. The reference items were measured twice, once before and once after the measurement (double injection of one replicate) of the test item. Two individual octanol / water partition coefficients log Pow for the test item were calculated by experimentally determining its capacity factor k and inserting k into the equation obtained from the first and second calibration graph. The, mean value was calculated from these individual log Pow values to be logPow 3.07 at 20°C.
Reference
Calibration Data of the Reference Items
Reference item |
log Pow |
1st Calibration |
2nd Calibration |
||||
|
|
tR1 [min] |
k |
log k |
tR2 [min] |
k |
log k |
Acetophenone |
1.7 |
1.951 |
2.90 |
0.462 |
1.953 |
2.90 |
0.463 |
Nitrobenzene |
1.9 |
2.698 |
4.39 |
0.643 |
2.701 |
4.40 |
0.643 |
Methyl benzoate |
2.1 |
3.042 |
5.08 |
0.706 |
3.043 |
5.08 |
0.706 |
Toluene |
2.7 |
5.964 |
10.9 |
1.04 |
5.961 |
10.9 |
1.04 |
Ethylbenzene |
3.2 |
9.373 |
17.7 |
1.25 |
9.363 |
17.7 |
1.25 |
Phenyl benzoate |
3.6 |
9.254 |
17.5 |
1.24 |
9.258 |
17.5 |
1.24 |
Biphenyl |
4.0 |
17.489 |
34.0 |
1.53 |
17.496 |
34.0 |
1.53 |
Slope, Y-intercept and Correlation Coefficient of the Regression Line
|
1st Calibration |
2nd Calibration |
slope |
2.253 |
2.254 |
Y-intercept |
0.5316 |
0.5298 |
r2 |
0.9680 |
0.9681 |
r |
0.9839 |
0.9839 |
Retention Times, Capacity Factors and Partition Coefficients of test item
|
tR |
|
log k |
log Pow |
|
Test Item |
[min] |
k |
1st Calibration |
2nd Calibration |
|
|
7.213 |
13.42 |
1.128 |
3.07 ± 0.07 |
3.07 ± 0.07 |
|
7.207 |
13.40 |
1.127 |
2.89 to 3.25 (95 % CI) |
2.89 to 3.25 (95 % CI) |
Mean |
7.210 |
13.41 |
1.127 |
3.07 |
The mean value for partition coefficient log Pow of the test item was determined to be 3.07.
Description of key information
The partition coefficient log Pow of the test item was determiend to be 3.07 at 20 °C.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.07
- at the temperature of:
- 20 °C
Additional information
A study was conducted in accordance with OECD TG 117 and Regulation (EC) No 440/2008 method A.8 to determine the partition coefficient of the test substance using the HPLC method. The analytical determination was conducted using a HPLC-column (e.g. C18) coupled to diode array detector (DAD). Methanol and HPLC water in a ratio of 65:35 was used as mobile phase. Calibration was performed using seven reference items with known log Pow values. The reference items were measured twice, once before and once after the measurement (double injection of one replicate) of the test item. Two individual octanol / water partition coefficients log Pow for the test item were calculated by experimentally determining its capacity factor k and inserting k into the equation obtained from the first and second calibration graph. The, mean value was calculated from these individual log Pow values to be logPow 3.07 at 20°C.
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