Amines, C12-14-tert-alkyl, compds. with 2(3H)-benzothiazolethione

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

02 June 1971 to 09 September 1971

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1971

Report date:

1971

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: U.S. Federal Hazardous Substances Act

Version / remarks:

September 17, 1964

Deviations:

no

GLP compliance:

no

Test material

Test material information

1

Reference substance name:

Amines, C12-14-tert-alkyl, compds. with 2(3H)-benzothiazolethione

EC Number:

272-782-3

EC Name:

Amines, C12-14-tert-alkyl, compds. with 2(3H)-benzothiazolethione

Cas Number:

68911-68-2

Molecular formula:

N/A

IUPAC Name:

C12-14-tert-alkylamines, compds. with 2(3H)-benzothiazolethione

Test material form:

liquid

Specific details on test material used for the study:

- Description: Viscous, amber liquid with an unpleasant odor

Test animals / tissue source

Species:

rabbit

Strain:

not specified

Remarks:

Albino

Test system

Vehicle:

unchanged (no vehicle)

Controls:

yes, concurrent no treatment

Amount / concentration applied:

1 μL

Observation period (in vivo):

24, 48 and 72 hours following application

Details on study design:

J. H. Draize, “Dermal Toxicity,” in Appraisal od the Safety of Chemicals in Foods, Drugs and Cosmetics, The Staff of the Division of Pharmacology of the Federal and Drug Administration (Austin, Texas: The Editorial Committee of the Association of Food and Drug Officials of the United States, 1959), p. 51.

Results and discussion

In vivo

Results

Irritation parameter:

overall irritation score

Basis:

mean

Time point:

24/48/72 h

Score:

> 16 - < 83

Max. score:

110

Reversibility:

not fully reversible within: 72 hrs

Remarks on result:

positive indication of irritation

Any other information on results incl. tables

Irritative effects included moderate or marked corneal opacity and conjunctivitis and mild iritis in each animal. Onset of these irritative effects was within 24 hours following application and they were relatively unchanged in five animals throughout the study. Irritative effects subsided significantly in the sixth animal. Four animals exhibited bleeding of the conjunctivae at the 24- and/or 48-hour observations.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye) based on GHS criteria

Conclusions:

Application of the test material to the eyes of albino rabbits produced corneal opacity, conjunctivitis, iritis, and conjunctival bleeding.

Executive summary:

In a study conducted according to the U.S. Federal Hazardous Substances Act, the test material when applied undiluted to the eyes of albino rabbits produced corneal opacity, conjunctivitis, iritis, and conjunctival bleeding. The test material is classified as a Category 1 according to GHS.