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EC number: 445-090-6 | CAS number: 5614-37-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 18 January 2002 - 30 September 2002
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- no
Test material
- Reference substance name:
- -
- EC Number:
- 445-090-6
- EC Name:
- -
- Cas Number:
- 5614-37-9
- Molecular formula:
- C6 H12 O
- IUPAC Name:
- Cyclopentyl methyl ether
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- - Analytical purity: 99.8%
- Lot/batch No.: 010912
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 5 - 7 weeks
- Weight at study initiation: 103 - 130g
- Fasting period before study: Yes (overnight before dosing and for 4 hours after dosing)
- Housing: metal cages with wire mesh floors
- Diet (e.g. ad libitum): Adlibitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Minimum of five days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±3°C
- Humidity (%): 40 - 70%
- Photoperiod (hrs dark / hrs light): 12 hours light : 12 hours dark
IN-LIFE DATES: From: 11 February 2002 To:08 March 2002
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: 1% Aqueous methylcellulose
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 20 mg/mL or 200 mg/mL
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: 2000 mg/kg chosen as the starting dose for compliance with the guidelines. - Doses:
- Group 1: 2000 mg/kg (3 females)
Group 2: 200 mg/kg (3 females)
Group 3: 200 mg/kg (3 males) - No. of animals per sex per dose:
- 3 (see above)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: recorded on day 1 prior to dosing, day 8, and day 15. Body weights were also recorded on death if applicable.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, macropathology.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Mortality:
- Female: 2000 mg/kg bw; Number of animals: 3; Number of deaths: 2
Female: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0
Male: 200 mg/kg bw; Number of animals: 3; Number of deaths: 0 - Clinical signs:
- Signs of toxicity related to dose levels: Two females dosed at 2000 mg/kg died within six and a half- hours of dosing.
Clinical signs of reaction to treatment comprised of piloerection, seen in all rats at both dosages. These signs were accompanied in all females at 2000 mg/kg by salivation, abnormal gait, lethargy, reduced body temperature, prostration, shallow respiration and lacrimation with prominent eyes and hunched posture in one female at 2000 mg/kg. Among rats at 200 mg/kg signs include hunched posture in all males and one female and abnormal gait in all females and one male. Recovery of surviving rats, as judged by external appearance and behaviour, was complete by either Day 2 (all rats at 200 mg/kg) or Day 3 (female at 2000 mg/kg). - Body weight:
- All surviving animals were considered to have achieved satisfactory bodyweight gains throughout the study.
- Gross pathology:
- Macroscopic examination of both decedents revealed congestion (characterised by blood vessels injected) in the brain and thickened tissues and atrophy of the heart. Congestion and fluid contents were noted in the stomach and along the alimentary tract.
Effects on organs: No abnormalities were revealed for the remaining surviving animals at the macroscopic examination at study termination on Day 15.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute median lethal oral dose (LD50) to rats of the substance was demonstrated to be between 200 and 2000 mg/kg bodyweight.
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