4'-Ethyl-3-fluorbiphenyl-4-boronic acid

Particle size distribution (Granulometry)

Link to relevant study record(s)

Reference

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

04.08.2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions) - Method B: Fibre Length and Diameter Distributions

GLP compliance:

no

Type of method:

Laser scattering/diffraction

Type of particle tested:

primary particle

Type of distribution:

volumetric distribution

Key result

Percentile:

D50

Mean:

57 µm

Remarks on result:

other: no SD indicated

Percentile:

D10

Mean:

8 µm

Remarks on result:

other: no SD indicated

Percentile:

D90

Mean:

190 µm

Remarks on result:

other: no SD indicated

 The median particle size D50 (D (v, 0.5): 50 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D50 = 58.42 µm

2nd test series: D50 = 56.02 µm

The average of the median particle size D50 was: D50 = 57.2 µm

 

The particle size D10 (D (v,0.1): 10 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D10 = 8.21 µm

2nd test series: D10 = 7.89 µm

The average of the particle size D10 was: D10 = 8.1 µm

 

The particle size D90 (D (v, 0.9): 90 % of particle volume or particle mass with lower particle diameter) deduced from these distributions were:

1st test series: D90 = 194.03 µm

2nd test series: D90 = 187.01 µm

The average of the particle size D90 was: D90 = 190.5 µm

 

The paticle size distribution showed a polymodal distribution with two maxima. The first maximum was observed at approx. 2 µm and the second maximum was observed at approx. 100 µm.

Conclusions:

The median particle sizes D10, D50 and D90 were determined to be 8.1 µm, 57.2 µm and 190.5 µm, respectively.

Executive summary:

A study was conducted according to OECD TG 110 to determine the particle size distribution of the test item. The test item consisted o transparent, crystalline particles which appear partially needle-shaped. The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bar_g). After passing the analyser beam the sample was collected in a vacuum cleaner. After adjusting the laser, measuring the background and adjusting the correct particle concentration the measurement was started.

Description of key information

The median particle sizes D10, D50 and D90 were determined to be 8.1 µm, 57.2 µm and 190.5 µm, respectively.

Additional information

A study was conducted according to OECD TG 110 to determine the particle size distribution of the test item. The test item consisted o transparent, crystalline particles which appear partially needle-shaped. The particles were introduced to the analyser beam by the dry powder feeder by direct spraying through the measurement area. The powder was loosened by an integrated vibrator. The particles were dispersed and fed to the optical system by pressurized dry air (1.5 bar_g). After passing the analyser beam the sample was collected in a vacuum cleaner. After adjusting the laser, measuring the background and adjusting the correct particle concentration the measurement was started.