Registration Dossier
Registration Dossier
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EC number: 600-034-1 | CAS number: 1001417-33-9
Endpoint summary
Administrative data
Description of key information
In an adapted hydrolysis study it was clearly demonstrated that hydrolysis of DOC-6114 with water leads to the formation of free Ligand 6114, as determined by1H NMR spectroscopy.
All DOC-6114 employed is completely hydrolyzed and free Ligand 6114 is obtained.
Aquatic toxicity studies were therefore performed with the hydrolysis product Ligand 6114 (CAS 1042662 -40 -7).
Two acute aquatic studies are available.
The acute toxicity to Daphnia magna is assessed. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (April 2004) No 202, "Daphnia sp., Acute Immobilisation Test" referenced as Method C.2 of Commission Regulation (EC) No. 440/2008.
Exposure of Daphnia magna the test item gave EC50 values based on the nominal test concentrations of greater than100% v/v saturated solution. The NOEC was determined to be100% v/v saturated solution.
This study showed that there were no toxic effects at saturation.
A study was performed to assess the effect of the test item on the growth of the green alga Pseudokirchneriella subcapitata. The method followed that described in the OECD Guidelines for Testing of Chemicals (2006) No 201, "Freshwater Alga and Cyanobacteria, Growth Inhibition Test" under GLP.
Exposure of Pseudokirchneriella subcapitata to the test item gave EC50 values based on the nominal test concentrations of greater than100% v/v saturated solution. The NOEC was determined to be100% v/v saturated solution.
This study showed that there were no toxic effects at saturation.
Additional information
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