Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 217-370-6 | CAS number: 1825-62-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to analogue justification provided in IUCLID section 13.
- Reason / purpose for cross-reference:
- read-across source
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6 670 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Conclusions:
- An EC50 value of 6670 mg/L (nominal) for toxicity to microorganisms was determined in a reliable study conducted with a suitable source substance according to an appropriate test protocol, and in compliance with GLP.
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-12-09 to 1991-12-10
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to an appropriate OECD test guideline, and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- ISO 8192 (Water quality - Test for inhibition of oxygen consumption by activated sludge for carbonaceous and ammonium oxidation)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- GLP compliance:
- yes
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- activated sludge
- Details on inoculum:
- - Source: Laboratory treatment plant (taken 06/12/1991)
- Pretreatment: None - Limit test:
- no
- Remarks on exposure duration:
- Not specified, guideline says 30 min to 3hr
- Nominal and measured concentrations:
- 1000, 1800, 3200, 5600, 10000 mg/l
- Reference substance (positive control):
- yes
- Remarks:
- 3,5-dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6 670 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- Report states that respiration rate of 3,5 dichlorophenol was checked as a reference, but no results given.
- Conclusions:
- An EC50 value of 6670 mg/L (nominal) for toxicity to microorganisms was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Referenceopen allclose all
Test substance concentration (mg/l) |
Respiration rate (mg O2/l/h) |
% Inhibition respiration rate |
1000 |
39.0 |
0.0 |
1800 |
39.0 |
0.0 |
3200 |
34.0 |
5.6 |
5600 |
21.0 |
41.7 |
10000 |
8.6 |
76.1 |
Description of key information
EC50: 6670 mg/L (ISO 8192)
Key value for chemical safety assessment
- EC50 for microorganisms:
- 6 670 mg/L
Additional information
There are no data available on toxicity to activated sludge
microorganisms for ethoxytrimethylsilane (CAS 1825-62-3). In accordance
with Regulation (EC) No 1907/2006 Annex XI, 1.5 “Grouping of substances
and read-across” and in accordance with the read across assessment
framework (RAAF, ECHA 2017) a read-across from the hydrolysis product
trimethylsilanol (CAS 1066-40-6) has been applied to support the
environmental hazard assessment of ethoxytrimethylsilane. Details on the
read across justification can be found in the attached justification in
the respective target entry and in the overall justification for
grouping of substances attached in IUCLID Section 13.
The study with the analogue substance was performed according to ISO
8192 (GLP) with test concentrations up to 10000 mg/L. Activated sludge
was used as inoculum. Inhibition of total respiration was recorded
resulting in an EC50 of 6670 mg/L. Based on the result from the
hydrolysis product, ethoxytrimethylsilane is not assumed to inhibit the
degradation process in sewage treatment plants.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.