Registration Dossier
Registration Dossier
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EC number: 224-632-3 | CAS number: 4432-31-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because exposure of humans via inhalation is not likely taking into account the vapour pressure of the substance and/or the possibility of exposure to aerosols, particles or droplets of an inhalable size
- Justification for type of information:
- According to (EC) No 1907/2006, Annex VIII, 8.5, column 2, at least one other route for substances shall be tested for acute toxicity in addition to the oral route. However, due to the estimated very low vapour pressure (1.39e-4 Pa) of the substance, exposure of humans via inhalation of vapours is unlikely. No adverse effects have been observed (i) in an acute oral toxicity study at a limit dose of 2000 mg/kg bw and (ii) in a combined repeated dose up to the highest dose tested. Therefore, although the test material is a solid powder and exposure to dusts are possible, no adverse effects are expected and no additional study on acute inhalation toxicity was performed.
Data source
Materials and methods
Results and discussion
- Clinical signs:
- other:
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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