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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

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Reference
Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH : Please see attached Read Across supporting document in Section 13 which includes the following:
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
3. ANALOGUE APPROACH JUSTIFICATION
4. DATA MATRIX
Reason / purpose:
read-across source
Key result
Duration:
48 h
Dose descriptor:
EC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Key result
Duration:
48 h
Dose descriptor:
NOEC
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mobility
Conclusions:
Based on a read across approach to an analogue substance, the 48 hour EC50 was predicted to be >100mg/L and the 48 hour NOEC was predicted to be 100mg/L.
Executive summary:

A read across approach to an analogue substance was used to predict the Acute toxicity to Daphnia. The source and the target substance are Solvent Red 19E (N-(2-ethylhexyl)-1-[[2-methyl-4-[(2-methylphenyl)azo]phenyl]azo]naphthalen-2-amine) and Solvent Red 500 (N-(2-ethylhexyl)-1-[[3-methyl-4-[(3-ethylphenyl)azo]phenyl]azo]naphthalen-2-amine).

 

They have the same molecular weight, and the same structure, differing only in the position of the methyl groups on the aromatic rings.

Using QSAR tools, both materials give the same predicted outputs for both water solubility and Aquatic Toxicity. 

Experimental data for both materials also confirms that they are both insoluble. The target substance Solvent Red 500 is therefore concluded to have the same aquatic toxicity properties as Solvent Red 19E. See the Read Across justification document for further information.

Description of key information

Based on a read across approach to an analogue substance, the 48 hour EC50 was predicted to be >100mg/L and the 48 hour NOEC was predicted to be 100mg/L.

Key value for chemical safety assessment

EC50/LC50 for freshwater invertebrates:
100 mg/L

Additional information