Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-742-6 | CAS number: 27939-60-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was performed in 1978.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study was performed predating current guidelines
- Justification for type of information:
- The information is used for read across to Vertoliff.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: read-across information from an analogue is used
- Justification for type of information:
- The full read-across document can be found in the Acute Endpoint Summary in text and in the attached file.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 900 - <= 5 100
- Interpretation of results:
- other: Not acute harmful
- Remarks:
- in accordance with EU CLP (EC No. 1272/2008 and its updates)
- Conclusions:
- The acute oral toxicity test showed an LD50 of 3900 mg/kg bw.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4-dimethylcyclohex-3-ene-1-carbaldehyde
- EC Number:
- 268-264-1
- EC Name:
- 2,4-dimethylcyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 68039-49-6
- Molecular formula:
- C9H14O
- IUPAC Name:
- 2,4-dimethylcyclohex-3-ene-1-carbaldehyde
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 1.73, 2.47, 3.51 and 5.0 g/kg bw
- No. of animals per sex per dose:
- 10 animals (sex unspecified) per dose group
- Control animals:
- no
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 900 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 2 900 - <= 5 100
- Mortality:
- 3/10, 1/10, 3/10 and 9/10 animals died in the 4 day observation period after exposure to 1.73, 2.47, 3.51 and 5.0 g/kg, respectively.
- Clinical signs:
- other: - 1.73 g/kg: diarrhea, lethargy - 2.47 g/kg: lethargy, piloerection, diarrhea, ptosis - 3.51 g/kg: lethargy, diarrhea, piloerection, comatose - 5.0 g/kg: lethargy, piloerection, chromorhinorrhea
- Gross pathology:
- - 1.73 g/kg: Normal (6/10), exudate, nose/ mouth red (1/10), intestines, areas red (2/10), intestines, areas yellow (1/10), liver, dark (3/10), lungs, areas dark (3/10), kidney dark (4/10), spleen mottled (1/10).
- 2.47 g/kg: Exudate, anogenital, brown (1/10), intestines, areas yellow (1/10), liver mottled (6/10), kidney dark (4/10), kidney mottled (4/10), bladder, blood contained (1/10).
- 3.51 g/kg: Normal (4/10), cannibalized (1/10), exudate, nose/mouth, red (1/10), exudate nose/ mouth, clear (1/10), exudate, anogenital, brown (1/10), intestine, areas red (2/10), intestine, areas yellow (2/10), intestine, bloated (1/10), liver dark (3/10), liver mottled (1/10), lungs, areas dark (2/10), kidney dark (2/10), kidney mottled (1/10), spleen dark (2/10), spleen large (2/10).
- 5.0 g/kg: Exudate, nose/ mouth, yellow (5/10), Exudate, anogenital, brown (6/10), intestines, areas red (10/10), intestines, areas yellow (8/10), intestines, bloated (9/10), stomach bloated (1/10), liver dark (6/10), liver mottled (1/10), lungs, areas dark (2/10), lungs dark (6/10), lungs, fluorescent red (1/10), kidney dark (8/10), spleen dark (5/10), spleen large (3/10), bladder, blood contained (3/10).
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acute harmful
- Remarks:
- in accordance with EU CLP (EC No. 1272/2008 and its updates)
- Conclusions:
- The acute oral toxicity test showed an LD50 of 3900 mg/kg bw.
- Executive summary:
A pre-guideline study, equivalent to OECD guideline 401, was performed to identify the acute oral toxicity of the test substance. In this study 10 rats (sex unspecified) were administered with 1.73, 2.47, 3.51 and 5.0 g/kg bw. 3/10, 1/10, 3/10 and 9/10 animals died in the 4 day observation period after exposure to 1.73, 2.47, 3.51 and 5.0 g/kg, respectively. Some additional toxic effects included lethargy, piloerection and comatose. At necropsy, the following organs were affected: nose/mouth (exudate red, yellow and clear), anogenital (exudate), intestines (red and yellow and bloated), liver (mottled and dark), lungs (dark lungs), kidney (dark kidneys) and spleen (dark and large). These dose-related effects were likely irritant effects because the substance becomes an acid when oxidized. Under the conditions of the test, the acute oral LD50 for the test substance in rat was determined to be 3900 mg/ kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.