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EC number: 248-742-6 | CAS number: 27939-60-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was performed in 1978.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study was performed predating current guidelines
- Justification for type of information:
- The information is used for read across to Vertoliff.
Cross-reference
- Reason / purpose for cross-reference:
- read-across: supporting information
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: read-across information from an analogue is used
- Justification for type of information:
- The full read-across document can be found in the Endpoint Summary in text and in the attached file.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- other: Not acute harmful
- Remarks:
- in accordance with EU CLP (EC No. 1272/2008 and its updates)
- Conclusions:
- The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,4-dimethylcyclohex-3-ene-1-carbaldehyde
- EC Number:
- 268-264-1
- EC Name:
- 2,4-dimethylcyclohex-3-ene-1-carbaldehyde
- Cas Number:
- 68039-49-6
- Molecular formula:
- C9H14O
- IUPAC Name:
- 2,4-dimethylcyclohex-3-ene-1-carbaldehyde
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- Not specified
- Doses:
- 5.0 g/kg bw
- No. of animals per sex per dose:
- 10 animals (sex unspecified)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 2/10 animals died on the first day in the 14 day observation period after exposure to 5.0 g/kg bw test substance.
- Clinical signs:
- other: - Toxic signs: Anorexia, lessened mobility due to severe edema & eschar of exposure site, ptosis (droopiness of a body part) - Skin irritation: moderate redness (1/8), severe redness (7/8), moderate edema (4/8) and severe edema (4/8).
- Gross pathology:
- At necropsy, the following organs were affected and the following signs observed: yellow exudate in nose/ mouth (2/10), red areas in intestines (3/10), yellow areas in intestines (1/10), bloated intestines (1/10), intestines containing dark green substance (1/10), liver dark (5/10), liver mottled (1/10), liver white nodules (2/10), lungs with areas dark (2/10), kidney mottled (2/10), kidney pale (1/10), skin sloughing of exposure area (1/10), skin edema (8/10), skin redness (9/10), skin hard/ thick (6/10).
Applicant's summary and conclusion
- Interpretation of results:
- other: Not acute harmful
- Remarks:
- in accordance with EU CLP (EC No. 1272/2008 and its updates)
- Conclusions:
- The acute dermal toxicity test showed an LD50 > 5000 mg/kg bw.
- Executive summary:
A pre-guideline study, equivalent to OECD guideline 402, was performed to identify the acute dermal toxicity of the test substance. In this study 10 rabbits (sex unspecified) were administered with 5000 mg/kg test substance on the skin. Two out of ten animals died in the 14 day observation period after exposure to the test substance. Some additional toxic effects included anorexia, lessened mobility due to severe edema & eschar of exposure site, ptosis (droopiness of a body part) and skin irritation: moderate redness (1/8), severe redness (7/8), moderate edema (4/8) and severe edema (4/8). At necropsy, the following organs were affected and the following signs observed: yellow exudate in nose/ mouth (2/10), red areas in intestines (3/10), yellow areas in intestines (1/10), bloated intestines (1/10), intestines containing dark green substance (1/10), liver dark (5/10), liver mottled (1/10), liver white nodules (2/10), lungs with areas dark (2/10), kidney mottled (2/10), kidney pale (1/10), skin sloughing of exposure area (1/10), skin edema (8/10), skin redness (9/10), skin hard/ thick (6/10). Under the conditions of the test, the acute dermal LD50 for the substance in rabbits was > 5000 mg/ kg bw. Based on these results, the test substance is not considered to be acute harmful.
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