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EC number: 233-794-4 | CAS number: 10361-79-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The method of Draize et al. (1944) was used to study skin irritation in rabbits.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No further data on test animals reported.
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact and abraded skin
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- Not entirely clear.
- Observation period:
- 7 days (up to 35 days for animals exposed to the test chemical on abraded skin)
- Number of animals:
- 6, sex not specified
- Details on study design:
- TEST SITE: no data reported
REMOVAL OF TEST SUBSTANCE: no data reported
OBSERVATION TIME POINTS: not reported, but observations are reported after 24 h, 7 days, and 35 days (the latter only for abraded skin)
SCORING SYSTEM: Draize scoring system - Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 8
- Remarks on result:
- no indication of irritation
- Remarks:
- intact skin
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 8
- Max. score:
- 8
- Reversibility:
- fully reversible within: 35 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- abraded skin
- Irritant / corrosive response data:
- - Direct application of the test item to intact rabbit skin produced no irritation within 24 hours, and no delayed reaction after 7 days.
- On abraded skin, there was a severe reaction after 24 hours with a maximum irritation index of 8. No change in irritation index was observed over the following 14 days, but complete healing with scars of 25-30 mm in diameter occurred at 35 days.
- It was mentioned that the liberation of nascent hydrochloric acid from the test item by tissue fluids may explain the difference in response between intact and abraded skin. - Other effects:
- No additional information.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was found to be irritating to abraded skin, but non-irritating to intact skin. Therefore, and considering the requirements of current test guidelines, the test substance is considered to be not classified according to the CLP Regulation.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The method of Draize et al. (1944) was used to study ocular irritation in rabbits.
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- No further data on test animals reported.
- Vehicle:
- water
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL into the conjunctival sac of one eye of each rabbit
- Concentration (if solution): 1:1 aqueous solution - Duration of treatment / exposure:
- not reported
- Observation period (in vivo):
- 4 weeks total, post-application
- Number of animals or in vitro replicates:
- 3, sex not specified
- Details on study design:
- REMOVAL OF TEST SUBSTANCE: no data
SCORING SYSTEM: Draize scoring system - Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 20
- Max. score:
- 20
- Reversibility:
- fully reversible within: > 1 week
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 0
- Max. score:
- 80
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 0
- Max. score:
- 10
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No effects were observed on cornea or iris, however, increased blinking rate and a maximum irritation index of 20 on the conjunctiva were observed within 1 hour after application. The test item produced conjunctival ulcers which persisted for 1 week, after which complete healing occurred. Observations over the next 3 weeks did not disclose any residual damage to the eye structures.
- Interpretation of results:
- Category 2 (irritating to eyes) based on GHS criteria
- Conclusions:
- The test item was found to produce conjunctival ulcers in rabbits, which persisted for one week but after that healed completely. No effect was observed on cornea or iris. Based on the results of this study, the test item praseodymium trichloride would have to be classified as Eye irritant Cat. 2, according to the CLP Regulation.
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1963
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- Well performed study, however, the publication does not provide sufficient information to evaluate the results of the study taking into account current methodological requirements.
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 408 (Repeated Dose 90-Day Oral Toxicity Study in Rodents)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- other: CRW
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No further details on test animals reported.
- Route of administration:
- oral: feed
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- CONCENTRATIONS IN DIET: 0.01%, 0.1% and 1% in diet (i.e. 0.1, 1 and 10 g/kg food, respectively)
No further details on exposure reported. - Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No additional data.
- Duration of treatment / exposure:
- 90 days
- Frequency of treatment:
- daily
- Dose / conc.:
- 10 000 mg/kg diet
- Dose / conc.:
- 1 000 mg/kg diet
- Dose / conc.:
- 100 mg/kg diet
- Dose / conc.:
- 0 mg/kg diet
- No. of animals per sex per dose:
- 6 males and 6 females per dose
- Control animals:
- yes, plain diet
- Details on study design:
- No additional information.
- Positive control:
- Not specified.
- Observations and examinations performed and frequency:
- CAGE SIDE OBSERVATIONS: Not specified
DETAILED CLINICAL OBSERVATIONS: Not specified
BODY WEIGHT: Yes
- Time schedule for examinations: Every 2 weeks
HAEMATOLOGY: Yes
- Time schedule for collection of blood: Every 2 weeks
- Anaesthetic used for blood collection: Not specified
- Animals fasted: Not specified
- How many animals: Not specified
- Parameters examined: Total erythrocytes, total leucocytes, differential cell count, platelets, hemoglobin, hematocrit
CLINICAL CHEMISTRY: No
URINALYSIS: No
NEUROBEHAVIOURAL EXAMINATION: No
IMMUNOLOGY: No - Sacrifice and pathology:
- GROSS PATHOLOGY: Not specified
HISTOPATHOLOGY: Yes, upon completion of the study
- Tissues examined: heart, lung, liver, kidney, spleen, pancreas, adrenal, and small intestine - Other examinations:
- No data
- Statistics:
- Where appropriate, the results were analysed statistically by the method of Litchfield and Wilcoxon (1949).
- Clinical signs:
- not specified
- Mortality:
- not specified
- Body weight and weight changes:
- no effects observed
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- no effects observed
- Description (incidence and severity):
- The slight changes seen in the hemogram were probably related to the normal growth pattern of the animals and were within the range given by Gardner (1947). A normal pattern was also obtained with the differential cell counts.
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Immunological findings:
- not examined
- Organ weight findings including organ / body weight ratios:
- not examined
- Gross pathological findings:
- no effects observed
- Description (incidence and severity):
- At necropsy, all animals appeared normal.
- Neuropathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- no effects observed
- Description (incidence and severity):
- Histopathologic examination of the tissues showed no differences between medicated and control groups.
- Histopathological findings: neoplastic:
- not examined
- Other effects:
- not examined
- Details on results:
- No further details reported.
- Dose descriptor:
- NOAEL
- Effect level:
- >= 10 000 mg/kg diet
- Based on:
- test mat.
- Sex:
- male/female
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Critical effects observed:
- no
- Conclusions:
- The test item did not appear to have adverse effects on rats during and following 12 weeks of daily administration at dose levels of 0, 0.01%, 0.1% and 1% in diet, under the conditions of the test. No NOAEL could be determined due to absence of adverse effects. Therefore, an unbound NOAEL of >= 10000 mg/kg diet could be derived from the results of this study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 964
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Praseodymium trichloride
- EC Number:
- 233-794-4
- EC Name:
- Praseodymium trichloride
- Cas Number:
- 10361-79-2
- Molecular formula:
- PrCl3
- IUPAC Name:
- praseodymium trichloride
- Test material form:
- solid: particulate/powder
- Details on test material:
- No further details available
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CF-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- No further data on test animals reported.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- No further data on oral exposure reported.
- Doses:
- Not reported.
- No. of animals per sex per dose:
- 40 male mice (total).
- Control animals:
- not specified
- Details on study design:
- No further data on oral exposure reported.
- Statistics:
- LD50 and standard errors calculated using the method of Litchfield and Wilcoxon (1949).
Results and discussion
- Preliminary study:
- Not specified
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 4 500 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 4 054 - < 4 995
- Mortality:
- Some deaths occurred at 24 hours post-exposure. The peak of mortality was reported to occur at 48 h post-exposure. No further details reported.
- Clinical signs:
- Ataxia, writhing, laboured respiration, walking on toes with back arched, and sedation.
- Body weight:
- No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 of praseodymium trichloride to male mice was found to be 4500 mg/kg bw. The test substance is therefore considered not to be classified according to the CLP Regulation.
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