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Ecotoxicological information

Toxicity to microorganisms

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Reference
Endpoint:
toxicity to microorganisms, other
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
for read across
Justification for type of information:
Data for the target chemical is summarized based on the structurally similar read across chemicals
Reason / purpose:
read-across source
Reason / purpose:
read-across source
Qualifier:
according to
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two toxicity study of microorganism for the test chemical :
2. Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms.
3.Microtox test was performed on photobacterium
GLP compliance:
not specified
Analytical monitoring:
not specified
Vehicle:
not specified
Test organisms (species):
other: 2. Ruminococcus albus and Butyrivibrio fibrisolvens 3.Photobacterium
Test type:
static
Water media type:
freshwater
Total exposure duration:
5 min
Reference substance (positive control):
not specified
Dose descriptor:
IC50
Effect conc.:
100 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
growth inhibition
Remarks on result:
other: Growth inhibition were observed in Butyrivibrio fibrisolvens
Duration:
5 min
Dose descriptor:
EC50
Effect conc.:
37 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
other: Bioluminance
Remarks on result:
other: No other data
Validity criteria fulfilled:
not specified
Conclusions:
The test chemical ist likely to be toxic to microorganism atleast in the dose range of 37 - 100 mg/l
Executive summary:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms. Test conducted on two different organisms Ruminococcus albus and Butyrivibrio fibrisolvens. As the two different species Ruminococcus albus and Butyrivibrio fibrisolvens exposed with the test chemical nicotine sulphate, effect on the growth of organisms vary. The IGC for Ruminococcus albus was determine to be 10 mg/l and on the other species it was observed that the growth inhibited at 100 mg/l.

Above study was further supported by data for another structurally similar read across substance , microtox test was performed on Photobacterium phosphoreum for 5 min . The EC50 value was observed to be 37 mg/l. Test substance has inhibitory effects on microorganism. The test chemical ist likely to be toxic to microorganism  atleast in the dose range of 37 - 100 mg/l

Description of key information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms. Test conducted on two different organisms Ruminococcus albus and Butyrivibrio fibrisolvens. As the two different species Ruminococcus albus and Butyrivibrio fibrisolvens exposed with the test chemical nicotine sulphate, effect on the growth of organisms vary. The IGC for Ruminococcus albus was determine to be 10 mg/l and on the other species it was observed that the growth inhibited at 100 mg/l.

Above study was further supported by data for another structurally similar read across substance ,microtox test was performed on Photobacterium phosphoreum for 5 min . The EC50 value was observed to be 37 mg/l. Test substance has inhibitory effects on microorganism. The test chemical ist likely to be toxic to microorganism  atleast in the dose range of 37 - 100 mg/l

Key value for chemical safety assessment

EC50 for microorganisms:
37 mg/L

Additional information

Toxicity to microorganisms:

Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the toxicity of microorganism of the test chemical .The studies are as mentioned below:

Aim of this study was to determine the toxicity of test chemical on the growth of microorganisms. Test conducted on two different organisms Ruminococcus albus and Butyrivibrio fibrisolvens. As the two different species Ruminococcus albus and Butyrivibrio fibrisolvens exposed with the test chemical nicotine sulphate, effect on the growth of organisms vary. The IGC for Ruminococcus albus was determine to be 10 mg/l and on the other species it was observed that the growth inhibited at 100 mg/l.

Above study was further supported by data for another structurally similar read across substance ,microtox test was performed on Photobacterium phosphoreum for 5 min . The EC50 value was observed to be 37 mg/l. Test substance has inhibitory effects on microorganism. The test chemical ist likely to be toxic to microorganism  atleast in the dose range of 37 - 100 mg/l