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EC number: 221-029-7 | CAS number: 2978-58-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1969-05-06
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- In principle, the methods described in OECD Guideline 401 (Acute Oral Toxicity) were used.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 1,1-dimethylprop-3-ynylamine
- EC Number:
- 221-029-7
- EC Name:
- 1,1-dimethylprop-3-ynylamine
- Cas Number:
- 2978-58-7
- Molecular formula:
- C5H9N
- IUPAC Name:
- 2-methylbut-3-yn-2-amine
Constituent 1
- Specific details on test material used for the study:
- - Purity: assumed to contain 100% active ingredient
- Appearance: clear, colorless liquid, pungent odor
- Date received:1969-03-25
Test animals
- Species:
- rat
- Strain:
- other: Carworth (Sprague-Dawley-derived) strain
- Sex:
- male
Administration / exposure
- Route of administration:
- other: gastric intubation
- Vehicle:
- water
- Details on oral exposure:
- After a three to four-hour fasting period, the test material was administered by gastric intubation as a 50% weight-per-volume suspension in distilled water to groups of five male rats each at dosage levels of 100, 215, 464, 1000 and 2150 mg/kg of body weight.
- Doses:
- 100, 215, 464, 1000, 2150, and 4640 mg/kg bw
- No. of animals per sex per dose:
- 5 males per dose
- Control animals:
- no
- Details on study design:
- - Fasting period: three to four hours before exposure
- Diet (postdose): Purina Laboratory Chow and water available ad libitum
- Frequency of weighing: initially and terminally
- Frequency of observations on mortality and toxic effects: 1, 4 and 24 hours after dosing; once daily thereafter
- Necropsy of survivors performed: yes (on all animals which died during the study or were sacrificed at termination)
- Other examinations performed: clinical signs
- Duration of observation period following administration: 7 days
- Sacrifice: barbiturate (Diabutal) overdose after observation period - Statistics:
- Analysis of mortality data was performed according to Thompson, W. R., Bact. Rev. 11, 115-145, 1947, using the tables of Horn, H. J., Biometrics 11, 311, 1956. No confidence limits were determined due to "all-or-none" response.
Results and discussion
- Preliminary study:
- Not performed.
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 470 mg/kg bw
- Based on:
- test mat. (dissolved fraction)
- Mortality:
- Five of five male rats died on day four at the 2150 mg/kg bw level.
- Clinical signs:
- other: DOSE-DEPENDEND PRINCIPAL TOXIC EFFECTS - 100 mg/kg bw: no effects - 215 mg/kg bw: slight depression (1-24 hours) - 464 mg/kg bw: slight depression (1-24 hours) - 1000 mg/kg bw: labored respiration, ptosis, lacrimation, ataxia, bloody crust on eyes, and
- Gross pathology:
- AT DEATH
- 2150 mg/kg bw: dark red zone at corticomedullary junction of kidney, stomach distended with dark red fluid, soft consistency of stomach walls, lining of pyloric portion dark red, cardiac portion thickened and pink in color.
AT SACRIFICE
- no gross pathology observed
Any other information on results incl. tables
Table 1: Mortality after 1 h, 4 h, 24 h and 2 -7 d due to an initial application of an aqueous solution of the test substance at dose levels of 100, 215, 464, 1000 and 2150 mg/kg bw. Number of animals dead per number of animals tested, cumulative.
Time of Death |
|||||
Dose [mg/kg bw] |
Immediate |
Hours |
Days |
||
1 |
4 |
24 |
2 -7 |
||
100 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
215 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
464 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
1000 |
0/5 |
0/5 |
0/5 |
0/5 |
0/5 |
2150 |
0/5 |
0/5 |
5/5 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
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