(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Water solubility

Administrative data

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

5th March 1993 to 1st October 1993

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Test material

Test material information

Constituent 1

Results and discussion

Water solubility

Water solubility:

0.048 mg/L

Temp.:

22 °C

pH:

ca. 8.5

Any other information on results incl. tables

Table 1: Water solubility results

Time	Temperature °C	Flow rate mL/h	pH	Results mg/L	Mean mg/L	%RSD
8 H 00	22	25	8.05	0.0425	0.0476	10.85
9 H 00	22	25	8.54	0.0560
10 H 00	22	25	8.59	0.0450
11 H 00	22	25	8.67	0.0485
12 H 00	22	25	8.63	0.0460

%RSD : relative standard deviation

Applicant's summary and conclusion

Conclusions:

Interpretation of results: insoluble (< 0.1 mg/L)
The water solubility of the test article was determined to be 0.0476 mg/L.

Executive summary:

In a general physico-chemical properties study (13193), the water solubility of the test material was determined to be 0.0476 mg/L at 22 °C, according to Method A6 of EEC Directive 84/449 and OECD Guideline 105.