(1R)-1-[(4R,4aR,8aS)-2,6-bis(3,4-dimethylphenyl)tetrahydro[1,3]dioxino[5,4-d][1,3]dioxin-4-yl]ethane-1,2-diol

Density

Administrative data

Endpoint:

relative density

Type of information:

experimental study

Adequacy of study:

key study

Study period:

5th March 1993 to 1st October 1993

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1993

Report date:

1993

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.3 (Relative Density)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 109 (Density of Liquids and Solids)

Deviations:

no

Principles of method if other than guideline:

The relative density (A3) was performed at 22°C instead of 20 ± 0.5°C.

GLP compliance:

yes (incl. QA statement)

Type of method:

pycnometer method

Test material

Test material information

Constituent 1

Results and discussion

Density

Type:

relative density

Density:

0.72 other: (corresponds to D4(22))

Temp.:

22 °C

Any other information on results incl. tables

The different values of the volumetric mass of water are given in pages F5 – F6 of the “Handbook of chemistry and physics” 60^thedition – 1979-1980 – CRC Press.

 

	Measurement 1	Measurement 2	Measurement 3
Weight of empty pycnometer (in g) Weight of test article (in g) Weight of water (in g)	21.521 23.491 32.331	21.522 23.521 32.338	21.521 23.511 32.337
M test article / M water	0.727	0.727	0.727
Mean of the 3 measurements	0.727

Applicant's summary and conclusion

Conclusions:

The relative density D 22/4 of the test article was determined to be 0.725.

Executive summary:

In a general physico-chemical properties study (13193), the test material was determined have a relative density of 0.725 at 22.0 °C by the pycnometer method based on Method A3 of Commission Directive 92/69/EEC.