Registration Dossier
Registration Dossier
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EC number: 603-689-1 | CAS number: 132961-05-8
Melting point / freezing point
Administrative data
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25 June 1991 - 2 July 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: FDA guideline: Technical Assistance Document 3.06 (March 1987)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- other: Capillary method with photocell detection
Test material
- Reference substance name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- EC Number:
- 603-689-1
- Cas Number:
- 132961-05-8
- Molecular formula:
- C23H28F2N4O2
- IUPAC Name:
- 3-(2-{4-[(Z)-(2,4-DIFLUOROPHENYL)(HYDROXYIMINO)METHYL]PIPERIDIN-1-YL}ETHYL)-2-METHYL-6,7,8,9-TETRAHYDRO-4H-PYRIDO[1,2-A]PYRIMIDIN-4-ONE
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- - Batch: RT001624BEA011
- Purity: 99.1% (HPLC purity)
Results and discussion
Melting / freezing point
- Key result
- Melting / freezing pt.:
- 194.6 °C
- Decomposition:
- no
- Remarks on result:
- other: There was no information on decomposition mentioned in the report
Any other information on results incl. tables
Preliminary test
The observed melting point of the reference substance using the Reichert Heizbank is about 463 K (190°C).
The observed melting point of the test substance using the Reichert Heizbank is about 468 K (195°C).
Determination of the melting point using the Mettler apparatus
The mean melting point of the reference substance is 464.5 K (191.3°C) and the mean melting point of the test substance is 467.7 K (194.6°C).
Applicant's summary and conclusion
- Conclusions:
- The melting point of the test substance was determined via Capillary method with photocell detection and is determined to be 467.7K (194.6°C).
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